Micronutrient homeostasis

Mette M. Berger, Linda Sousse, Gordon L. Klein, Ludwik Branski, David Herndon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Burn injury is marked by a reduction in plasma concentration of most vitamins and trace elements, many of which play a major role as antioxidants. Following severe injury, the body is subject to substantial oxidative stress (direct lipid oxidation, inflammation, sepsis) as well as to endogenous endocrine changes generated by the stress response. Deficiencies in zinc and copper occur as a result of exudative loss in the burn wound and urinary wasting. The pathophysiology of deficiencies of ascorbic acid and vitamin E is less clear. Vitamin D becomes progressively deficient due to failure of skin to produce normal quantities. Other micronutrients for which deficiencies are reported serve as acute-phase reactants following systemic inflammation. Thus copper, zinc, iron, and chromium, among others, are subject to a greater demand for utilization. Antioxidant supplementation appears to have beneficial effects on morbidity and mortality; nutritional requirements are increased above RDA in the acute post-burn state, and precise antioxidant requirements have yet to be determined.

Original languageEnglish (US)
Title of host publicationTotal Burn Care
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Pages276-279.e2
ISBN (Electronic)9780323497428
ISBN (Print)9780323476614
DOIs
StatePublished - Nov 30 2017

Fingerprint

Micronutrients
Homeostasis
Antioxidants
Zinc
Copper
Wounds and Injuries
Ascorbic Acid Deficiency
Inflammation
Nutritional Requirements
Acute-Phase Proteins
Trace Elements
Chromium
Vitamin E
Burns
Vitamin D
Vitamins
Sepsis
Oxidative Stress
Iron
Morbidity

Keywords

  • Aluminum
  • Chromium
  • Copper
  • Critical illness
  • Exudates
  • Micronutrients
  • Selenium
  • Vitamin C
  • Vitamin D
  • Vitamin E
  • Vitamin K
  • Zinc

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Berger, M. M., Sousse, L., Klein, G. L., Branski, L., & Herndon, D. (2017). Micronutrient homeostasis. In Total Burn Care: Fifth Edition (pp. 276-279.e2). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-47661-4.00026-5

Micronutrient homeostasis. / Berger, Mette M.; Sousse, Linda; Klein, Gordon L.; Branski, Ludwik; Herndon, David.

Total Burn Care: Fifth Edition. Elsevier Inc., 2017. p. 276-279.e2.

Research output: Chapter in Book/Report/Conference proceedingChapter

Berger, MM, Sousse, L, Klein, GL, Branski, L & Herndon, D 2017, Micronutrient homeostasis. in Total Burn Care: Fifth Edition. Elsevier Inc., pp. 276-279.e2. https://doi.org/10.1016/B978-0-323-47661-4.00026-5
Berger MM, Sousse L, Klein GL, Branski L, Herndon D. Micronutrient homeostasis. In Total Burn Care: Fifth Edition. Elsevier Inc. 2017. p. 276-279.e2 https://doi.org/10.1016/B978-0-323-47661-4.00026-5
Berger, Mette M. ; Sousse, Linda ; Klein, Gordon L. ; Branski, Ludwik ; Herndon, David. / Micronutrient homeostasis. Total Burn Care: Fifth Edition. Elsevier Inc., 2017. pp. 276-279.e2
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