TY - JOUR
T1 - MicroRNAs in cancer
AU - Yong, Sun Lee
AU - Dutta, Anindya
N1 - Funding Information:
G.A.C. is supported as a fellow at The University of Texas M. D. Anderson Research Trust, as a fellow of The University of Texas System Regents Research Scholar, and by the Ladjevardian Regents Research Scholar Fund. Work in Dr Calin's laboratory is supported in part by an NIH RO1 grant, by a DOD Breast Cancer Idea Award, by a Breast Cancer SPORE Developmental Research Award, by an Ovarian Cancer SPORE Developmental Research Award, by a CTT/3I-TD grant, and by 2009 Seena Magowitz—Pancreatic Cancer Action Network—AACR Pilot Grant. M.I. is an American Cancer Society Research Scholar.
PY - 2009/2
Y1 - 2009/2
N2 - Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.
AB - Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.
KW - Diagnosis and prognosis
KW - MicroRNA expression profile
KW - Oncogene
KW - Therapy
KW - Tumor suppressor
KW - Tumorigenesis
UR - http://www.scopus.com/inward/record.url?scp=66149138833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66149138833&partnerID=8YFLogxK
U2 - 10.1146/annurev.pathol.4.110807.092222
DO - 10.1146/annurev.pathol.4.110807.092222
M3 - Review article
C2 - 18817506
AN - SCOPUS:66149138833
SN - 1553-4006
VL - 4
SP - 199
EP - 227
JO - Annual Review of Pathology: Mechanisms of Disease
JF - Annual Review of Pathology: Mechanisms of Disease
ER -