MicroRNAs in cancer

Sun Lee Yong; Anindya Dutta

doi:10.1146/annurev.pathol.4.110807.092222

MicroRNAs in cancer

Sun Lee Yong, Anindya Dutta

Research output: Contribution to journal › Review article › peer-review

923 Scopus citations

Abstract

Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.

Original language	English (US)
Pages (from-to)	199-227
Number of pages	29
Journal	Annual Review of Pathology: Mechanisms of Disease
Volume	4
DOIs	https://doi.org/10.1146/annurev.pathol.4.110807.092222
State	Published - Feb 2009
Externally published	Yes

Keywords

Diagnosis and prognosis
MicroRNA expression profile
Oncogene
Therapy
Tumor suppressor
Tumorigenesis

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1146/annurev.pathol.4.110807.092222

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title = "MicroRNAs in cancer",

abstract = "Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.",

keywords = "Diagnosis and prognosis, MicroRNA expression profile, Oncogene, Therapy, Tumor suppressor, Tumorigenesis",

author = "Yong, {Sun Lee} and Anindya Dutta",

note = "Funding Information: G.A.C. is supported as a fellow at The University of Texas M. D. Anderson Research Trust, as a fellow of The University of Texas System Regents Research Scholar, and by the Ladjevardian Regents Research Scholar Fund. Work in Dr Calin's laboratory is supported in part by an NIH RO1 grant, by a DOD Breast Cancer Idea Award, by a Breast Cancer SPORE Developmental Research Award, by an Ovarian Cancer SPORE Developmental Research Award, by a CTT/3I-TD grant, and by 2009 Seena Magowitz—Pancreatic Cancer Action Network—AACR Pilot Grant. M.I. is an American Cancer Society Research Scholar.",

year = "2009",

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doi = "10.1146/annurev.pathol.4.110807.092222",

language = "English (US)",

volume = "4",

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N2 - Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.

AB - Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.

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KW - Tumorigenesis

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MicroRNAs in cancer

Abstract

Keywords

ASJC Scopus subject areas

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