MicroRNAs in cancer

Sun Lee Yong, Anindya Dutta

Research output: Contribution to journalArticle

471 Citations (Scopus)

Abstract

Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.

Original languageEnglish (US)
Pages (from-to)199-227
Number of pages29
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume4
DOIs
StatePublished - Feb 2009
Externally publishedYes

Fingerprint

MicroRNAs
microRNA
neoplasms
Neoplasms
angiogenesis
metastasis
prognosis
etiology
apoptosis
Biological Sciences
Apoptosis
therapeutics
Neoplasm Metastasis

Keywords

  • Diagnosis and prognosis
  • MicroRNA expression profile
  • Oncogene
  • Therapy
  • Tumor suppressor
  • Tumorigenesis

ASJC Scopus subject areas

  • Plant Science
  • Medicine(all)

Cite this

MicroRNAs in cancer. / Yong, Sun Lee; Dutta, Anindya.

In: Annual Review of Pathology: Mechanisms of Disease, Vol. 4, 02.2009, p. 199-227.

Research output: Contribution to journalArticle

Yong, Sun Lee ; Dutta, Anindya. / MicroRNAs in cancer. In: Annual Review of Pathology: Mechanisms of Disease. 2009 ; Vol. 4. pp. 199-227.
@article{287b1084e791406cabfd0b03541c1195,
title = "MicroRNAs in cancer",
abstract = "Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.",
keywords = "Diagnosis and prognosis, MicroRNA expression profile, Oncogene, Therapy, Tumor suppressor, Tumorigenesis",
author = "Yong, {Sun Lee} and Anindya Dutta",
year = "2009",
month = "2",
doi = "10.1146/annurev.pathol.4.110807.092222",
language = "English (US)",
volume = "4",
pages = "199--227",
journal = "Annual Review of Phytopathology",
issn = "1553-4006",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - MicroRNAs in cancer

AU - Yong, Sun Lee

AU - Dutta, Anindya

PY - 2009/2

Y1 - 2009/2

N2 - Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.

AB - Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.

KW - Diagnosis and prognosis

KW - MicroRNA expression profile

KW - Oncogene

KW - Therapy

KW - Tumor suppressor

KW - Tumorigenesis

UR - http://www.scopus.com/inward/record.url?scp=66149138833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149138833&partnerID=8YFLogxK

U2 - 10.1146/annurev.pathol.4.110807.092222

DO - 10.1146/annurev.pathol.4.110807.092222

M3 - Article

C2 - 18817506

AN - SCOPUS:66149138833

VL - 4

SP - 199

EP - 227

JO - Annual Review of Phytopathology

JF - Annual Review of Phytopathology

SN - 1553-4006

ER -