MicroRNAs in Inflammatory Bowel Disease and Its Complications

Srikruthi S. Krishnachaitanya, Max Liu, Kenichi Fujise, Qingjie Li

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Inflammatory bowel disease (IBD), classified primarily between Crohn’s disease and ulcerative colitis, is a collection of chronic gastrointestinal inflammatory conditions that cause multiple complications because of systemic alterations in the immune response. One major player is microRNA (miRNA), which is found to be associated with multiple pathways in mediating inflammation, especially those of a chronic nature in IBD, as well as irritable bowel syndrome. Although there have been studies linking miRNA alterations in IBD, even differentiating Crohn’s disease and ulcerative colitis, this review focuses mainly on how miRNAs cause and mechanistically influence the pathologic complications of IBD. In addition to its role in the well-known progression towards colorectal cancer, we also emphasize how miRNA manifests the many extraintestinal complications in IBD such as cardiovascular diseases; neuropsychiatric conditions such as depression and anxiety disorders; and others, including various musculoskeletal, dermatologic, ocular, and hepatobiliary complications. We conclude through a description of its potential use in bettering diagnostics and the future treatment of IBD and its systemic symptoms.

Original languageEnglish (US)
Article number8751
JournalInternational journal of molecular sciences
Volume23
Issue number15
DOIs
StatePublished - Aug 2022

Keywords

  • Crohn’s disease
  • colitis-associated cancer
  • extraintestinal manifestations
  • non-coding RNA
  • ulcerative colitis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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