Microscopic pulmonary tumor emboli associated with dyspnea

R. D. Kane, H. K. Hawkins, J. A. Miller, P. S. Noce

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

A syndrome is described in which severe, clinically unexplained dyspnea is found at autopsy to be caused by multiple microscopic tumor emboli. Such a situation was found in 8 of 16 cases of multiple microscopic tumor emboli in the pulmonary arteries without significant lymphatic or parenchymal involvement of the lungs. The origins of tumor emboli included carcinomas of the prostate, breast, stomach, pancreas, and liver. In the 8 cases that presented with unexplained dyspnea, initial physical, roentgenographic, and electrocardiographic examinations were not diagnostic. Clinical or morphological evidence of cor pulmonale was present in only 5 of these 8 cases. The tumor emboli did not invade the walls of pulmonary vessels but were frequently associated with thrombi. Recognition of this clinicopathologic entity becomes important as progress is made in cancer therapy.

Original languageEnglish (US)
Pages (from-to)1473-1482
Number of pages10
JournalCancer
Volume36
Issue number4
StatePublished - 1975
Externally publishedYes

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Embolism
Dyspnea
Lung
Neoplasms
Pulmonary Heart Disease
Pulmonary Artery
Prostate
Pancreas
Autopsy
Stomach
Thrombosis
Breast Neoplasms
Liver
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kane, R. D., Hawkins, H. K., Miller, J. A., & Noce, P. S. (1975). Microscopic pulmonary tumor emboli associated with dyspnea. Cancer, 36(4), 1473-1482.

Microscopic pulmonary tumor emboli associated with dyspnea. / Kane, R. D.; Hawkins, H. K.; Miller, J. A.; Noce, P. S.

In: Cancer, Vol. 36, No. 4, 1975, p. 1473-1482.

Research output: Contribution to journalArticle

Kane, RD, Hawkins, HK, Miller, JA & Noce, PS 1975, 'Microscopic pulmonary tumor emboli associated with dyspnea', Cancer, vol. 36, no. 4, pp. 1473-1482.
Kane RD, Hawkins HK, Miller JA, Noce PS. Microscopic pulmonary tumor emboli associated with dyspnea. Cancer. 1975;36(4):1473-1482.
Kane, R. D. ; Hawkins, H. K. ; Miller, J. A. ; Noce, P. S. / Microscopic pulmonary tumor emboli associated with dyspnea. In: Cancer. 1975 ; Vol. 36, No. 4. pp. 1473-1482.
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