Microsporidiasis

Ahmad Ashfaq, A. Clinton White

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Microsporidia are obligate intracellular spore-forming organisms. Several species of microsporidia cause human disease, mainly in immunocompromised hosts. The spectrum of disease varies from diarrhea, keratoconjunctivitis to disseminated infection involving multiple organs. CNS disease is a rare manifestation usually seen in compromised hosts as part of a disseminated infection. Only 12 cases of CNS microsporidiosis have been reported in the literature. Clinically, they usually present with signs and symptoms of encephalitis and seizures. Diagnosis often requires brain biopsy, but spores can occasionally be found in other sites. Albendazole and fumagillin have been successfully used in treating microsporidiosis at other sites, but their role in CNS infection is unclear.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Pages183-191
Number of pages9
DOIs
StatePublished - 2013

Publication series

NameHandbook of Clinical Neurology
Volume114
ISSN (Print)0072-9752

Keywords

  • Encephalitozoon
  • Fumagillin
  • Microsporidiosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Ashfaq, A., & White, A. C. (2013). Microsporidiasis. In Handbook of Clinical Neurology (pp. 183-191). (Handbook of Clinical Neurology; Vol. 114). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-53490-3.00012-1