Microsporidiasis

Ahmad Ashfaq, A. Clinton White

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Microsporidia are obligate intracellular spore-forming organisms. Several species of microsporidia cause human disease, mainly in immunocompromised hosts. The spectrum of disease varies from diarrhea, keratoconjunctivitis to disseminated infection involving multiple organs. CNS disease is a rare manifestation usually seen in compromised hosts as part of a disseminated infection. Only 12 cases of CNS microsporidiosis have been reported in the literature. Clinically, they usually present with signs and symptoms of encephalitis and seizures. Diagnosis often requires brain biopsy, but spores can occasionally be found in other sites. Albendazole and fumagillin have been successfully used in treating microsporidiosis at other sites, but their role in CNS infection is unclear.

Original languageEnglish (US)
Pages (from-to)183-191
Number of pages9
JournalHandbook of Clinical Neurology
Volume114
DOIs
StatePublished - 2013

Fingerprint

Microsporidiosis
Microsporidia
Spores
Infection
Keratoconjunctivitis
Albendazole
Central Nervous System Diseases
Immunocompromised Host
Encephalitis
Signs and Symptoms
Diarrhea
Seizures
Biopsy
Brain

Keywords

  • Encephalitozoon
  • Fumagillin
  • Microsporidiosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Microsporidiasis. / Ashfaq, Ahmad; White, A. Clinton.

In: Handbook of Clinical Neurology, Vol. 114, 2013, p. 183-191.

Research output: Contribution to journalArticle

Ashfaq, Ahmad ; White, A. Clinton. / Microsporidiasis. In: Handbook of Clinical Neurology. 2013 ; Vol. 114. pp. 183-191.
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