Microtubule-dependent vesicle transport

Modulation of channel and transporter activity in liver and kidney

Sarah F. Hamm-Alvarez, Michael Sheetz

Research output: Contribution to journalReview article

105 Citations (Scopus)

Abstract

Microtubule-based vesicle transport driven by kinesin and cytoplasmic dynein motor proteins facilitates several membrane-trafficking steps including elements of endocytosis and exocytosis in many different cell types. Most early studies on the role of microtubule-dependent vesicle transport in membrane trafficking focused either on neurons or on simple cell lines. More recently, other work has considered the role of microtubule- based vesicle transport in other physiological systems, including kidney and liver. Investigation of the role of microtubule-based vesicle transport in membrane trafficking in cells of the kidney and liver suggests a major role for microtubule-based vesicle transport in the rapid and directed movement of ion channels and transporters to and from the apical plasma membranes, events essential for kidney and liver function and homeostasis. This review discusses the evidence supporting a role for microtubule-based vesicle transport and the motor proteins, kinesin and cytoplasmic dynein, in different aspects of membrane trafficking in cells of the kidney and liver, with emphasis on those functions such as maintenance of ion channel and transporter composition in apical membranes that are specialized functions of these organs. Evidence that defects in microtubule-based transport contribute to diseases of the kidney and liver is also discussed.

Original languageEnglish (US)
Pages (from-to)1109-1129
Number of pages21
JournalPhysiological Reviews
Volume78
Issue number4
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Transport Vesicles
Microtubules
Kidney
Liver
Cytoplasmic Dyneins
Membranes
Kinesin
Ion Channels
Exocytosis
Kidney Diseases
Endocytosis
Liver Diseases
Carrier Proteins
Homeostasis
Maintenance
Cell Membrane
Neurons
Cell Line

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Microtubule-dependent vesicle transport : Modulation of channel and transporter activity in liver and kidney. / Hamm-Alvarez, Sarah F.; Sheetz, Michael.

In: Physiological Reviews, Vol. 78, No. 4, 01.01.1998, p. 1109-1129.

Research output: Contribution to journalReview article

@article{3fcf3893a82746fcbea2a3d75cb10e1e,
title = "Microtubule-dependent vesicle transport: Modulation of channel and transporter activity in liver and kidney",
abstract = "Microtubule-based vesicle transport driven by kinesin and cytoplasmic dynein motor proteins facilitates several membrane-trafficking steps including elements of endocytosis and exocytosis in many different cell types. Most early studies on the role of microtubule-dependent vesicle transport in membrane trafficking focused either on neurons or on simple cell lines. More recently, other work has considered the role of microtubule- based vesicle transport in other physiological systems, including kidney and liver. Investigation of the role of microtubule-based vesicle transport in membrane trafficking in cells of the kidney and liver suggests a major role for microtubule-based vesicle transport in the rapid and directed movement of ion channels and transporters to and from the apical plasma membranes, events essential for kidney and liver function and homeostasis. This review discusses the evidence supporting a role for microtubule-based vesicle transport and the motor proteins, kinesin and cytoplasmic dynein, in different aspects of membrane trafficking in cells of the kidney and liver, with emphasis on those functions such as maintenance of ion channel and transporter composition in apical membranes that are specialized functions of these organs. Evidence that defects in microtubule-based transport contribute to diseases of the kidney and liver is also discussed.",
author = "Hamm-Alvarez, {Sarah F.} and Michael Sheetz",
year = "1998",
month = "1",
day = "1",
doi = "10.1152/physrev.1998.78.4.1109",
language = "English (US)",
volume = "78",
pages = "1109--1129",
journal = "Physiological Reviews",
issn = "0031-9333",
publisher = "American Physiological Society",
number = "4",

}

TY - JOUR

T1 - Microtubule-dependent vesicle transport

T2 - Modulation of channel and transporter activity in liver and kidney

AU - Hamm-Alvarez, Sarah F.

AU - Sheetz, Michael

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Microtubule-based vesicle transport driven by kinesin and cytoplasmic dynein motor proteins facilitates several membrane-trafficking steps including elements of endocytosis and exocytosis in many different cell types. Most early studies on the role of microtubule-dependent vesicle transport in membrane trafficking focused either on neurons or on simple cell lines. More recently, other work has considered the role of microtubule- based vesicle transport in other physiological systems, including kidney and liver. Investigation of the role of microtubule-based vesicle transport in membrane trafficking in cells of the kidney and liver suggests a major role for microtubule-based vesicle transport in the rapid and directed movement of ion channels and transporters to and from the apical plasma membranes, events essential for kidney and liver function and homeostasis. This review discusses the evidence supporting a role for microtubule-based vesicle transport and the motor proteins, kinesin and cytoplasmic dynein, in different aspects of membrane trafficking in cells of the kidney and liver, with emphasis on those functions such as maintenance of ion channel and transporter composition in apical membranes that are specialized functions of these organs. Evidence that defects in microtubule-based transport contribute to diseases of the kidney and liver is also discussed.

AB - Microtubule-based vesicle transport driven by kinesin and cytoplasmic dynein motor proteins facilitates several membrane-trafficking steps including elements of endocytosis and exocytosis in many different cell types. Most early studies on the role of microtubule-dependent vesicle transport in membrane trafficking focused either on neurons or on simple cell lines. More recently, other work has considered the role of microtubule- based vesicle transport in other physiological systems, including kidney and liver. Investigation of the role of microtubule-based vesicle transport in membrane trafficking in cells of the kidney and liver suggests a major role for microtubule-based vesicle transport in the rapid and directed movement of ion channels and transporters to and from the apical plasma membranes, events essential for kidney and liver function and homeostasis. This review discusses the evidence supporting a role for microtubule-based vesicle transport and the motor proteins, kinesin and cytoplasmic dynein, in different aspects of membrane trafficking in cells of the kidney and liver, with emphasis on those functions such as maintenance of ion channel and transporter composition in apical membranes that are specialized functions of these organs. Evidence that defects in microtubule-based transport contribute to diseases of the kidney and liver is also discussed.

UR - http://www.scopus.com/inward/record.url?scp=0031754514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031754514&partnerID=8YFLogxK

U2 - 10.1152/physrev.1998.78.4.1109

DO - 10.1152/physrev.1998.78.4.1109

M3 - Review article

VL - 78

SP - 1109

EP - 1129

JO - Physiological Reviews

JF - Physiological Reviews

SN - 0031-9333

IS - 4

ER -