Microvascular changes in large flame burn wound in sheep

Hiroyuki Sakurai, Motohiro Nozaki, Lillian D. Traber, Hal K. Hawkins, Daniel L. Traber

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Advances in local wound management with early excisional therapy have decreased morbidity and mortality of massive third-degree burn patients. Although blood redistribution within burned tissue is of clinical interest, few studies have longitudinally determined the regional blood flow of various layers of the burn wound. We used a conscious ovine model in which animals were subjected to 40% third degree burn. Burned tissue was divided into the four layers (i.e. skin, panniculus carnosus, adipose tissue, and skeletal muscle), and regional blood flow was determined separately, with fluorescent microspheres, while measuring systemic hemodynamics and total burned tissue microvascular fluid flux. The subburn adipose tissue exhibited a remarkable biphasic alteration in regional blood flow, whereas the skin layer showed only decreased blood flow during the whole experimental period. The increase in blood flow to the adipose tissue seems to be related to a sustained fluid filtrate in the postresuscitation period, resulting in edema formation mainly located in the adipose tissue at the endpoint.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalBurns
Volume28
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Adipose Tissue
Sheep
Regional Blood Flow
Wounds and Injuries
Skin
Secondary Prevention
Microspheres
Edema
Skeletal Muscle
Hemodynamics
Morbidity
Mortality

Keywords

  • Burn
  • Early excision
  • Fluorescent microspheres
  • Regional blood flow

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Sakurai, H., Nozaki, M., Traber, L. D., Hawkins, H. K., & Traber, D. L. (2002). Microvascular changes in large flame burn wound in sheep. Burns, 28(1), 3-9. https://doi.org/10.1016/S0305-4179(01)00067-5

Microvascular changes in large flame burn wound in sheep. / Sakurai, Hiroyuki; Nozaki, Motohiro; Traber, Lillian D.; Hawkins, Hal K.; Traber, Daniel L.

In: Burns, Vol. 28, No. 1, 2002, p. 3-9.

Research output: Contribution to journalArticle

Sakurai, H, Nozaki, M, Traber, LD, Hawkins, HK & Traber, DL 2002, 'Microvascular changes in large flame burn wound in sheep', Burns, vol. 28, no. 1, pp. 3-9. https://doi.org/10.1016/S0305-4179(01)00067-5
Sakurai H, Nozaki M, Traber LD, Hawkins HK, Traber DL. Microvascular changes in large flame burn wound in sheep. Burns. 2002;28(1):3-9. https://doi.org/10.1016/S0305-4179(01)00067-5
Sakurai, Hiroyuki ; Nozaki, Motohiro ; Traber, Lillian D. ; Hawkins, Hal K. ; Traber, Daniel L. / Microvascular changes in large flame burn wound in sheep. In: Burns. 2002 ; Vol. 28, No. 1. pp. 3-9.
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