Middle ear fluid (MEF) levels of cefpodoxime in pediatric patients with acute otitis media (AOM)

M. T. Borin, D. P. McCormick, R. H. Schwartz, K. K. Ryan

Research output: Contribution to journalArticle

Abstract

The penetration of cefpodoxime into the middle ear of 26 pediatric patients (age, 6 mo to 9 yr) with AOM was evaluated after administration of cefpodoxime proxetil oral suspension 5 mg/kg bid or 10 mg/kg qd. After at least one complete day of treatment, tympanocentesis was performed during a 2-8 hr interval after the morning dose; a blood sample was collected at the same time as the MEF. Drug concentrations in MEF and plasma were determined using a HPLC method with tandem mass selective detection. Median (range) cefpodoxime concentrations in MEF are shown in the following table: 5 mg/kg bid (N=12) 10 mg/kg qd (N=14) Collection Time(hr) n Conc(μg/mL) n Conc (μg/mL) 2-4 4 2.49 (2.0-3.3) 2 1.70 (1.5, 1.9) 4-6 5 0.50 (0.35-1.6) 6 3.24 (2.1-12.2) 6-8 7 0.97 (0.33-1.2) 8 2.21 (0.20-4.1) The MEF/plasma cefpodoxime concentration ratio ranged from 0.25 to 2.6 and from 0.13 to 3.2 in the 5 mg/kg bid and 10 mg/kg qd groups, respectively. MEF cefpodoxime levels ≥0.50 μg/mL were attained in 88% of the patients. These levels exceed the minimum inhibitory concentration for the majority of S pneumoniae, H influenzae, and M catarrhalis isolates, the most common etiological agents of AOM, and thus support cefpodoxime's utility in treating this disease.

Original languageEnglish (US)
Number of pages1
JournalClinical Pharmacology and Therapeutics
Volume61
Issue number2
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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