Middle East Respiratory Syndrome Vaccine Candidates

Cautious Optimism

Craig Schindewolf, Vineet Menachery

Research output: Contribution to journalReview article

Abstract

Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

Original languageEnglish (US)
JournalViruses
Volume11
Issue number1
DOIs
StatePublished - Jan 17 2019

Fingerprint

Coronavirus Infections
Vaccines
Coronavirus
Animal Models
Clinical Trials
Optimism

Keywords

  • animal models
  • coronavirus spike glycoprotein
  • correlates of immunity
  • Middle East respiratory syndrome coronavirus
  • severe acute respiratory syndrome coronavirus
  • vaccine platforms

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Middle East Respiratory Syndrome Vaccine Candidates : Cautious Optimism. / Schindewolf, Craig; Menachery, Vineet.

In: Viruses, Vol. 11, No. 1, 17.01.2019.

Research output: Contribution to journalReview article

@article{a06ec8f7e7ca438a8b855d96af15a9d9,
title = "Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism",
abstract = "Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.",
keywords = "animal models, coronavirus spike glycoprotein, correlates of immunity, Middle East respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus, vaccine platforms",
author = "Craig Schindewolf and Vineet Menachery",
year = "2019",
month = "1",
day = "17",
doi = "10.3390/v11010074",
language = "English (US)",
volume = "11",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

TY - JOUR

T1 - Middle East Respiratory Syndrome Vaccine Candidates

T2 - Cautious Optimism

AU - Schindewolf, Craig

AU - Menachery, Vineet

PY - 2019/1/17

Y1 - 2019/1/17

N2 - Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

AB - Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

KW - animal models

KW - coronavirus spike glycoprotein

KW - correlates of immunity

KW - Middle East respiratory syndrome coronavirus

KW - severe acute respiratory syndrome coronavirus

KW - vaccine platforms

UR - http://www.scopus.com/inward/record.url?scp=85060124569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060124569&partnerID=8YFLogxK

U2 - 10.3390/v11010074

DO - 10.3390/v11010074

M3 - Review article

VL - 11

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 1

ER -