Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism

Craig Schindewolf; Vineet Menachery

doi:10.3390/v11010074

Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism

Craig Schindewolf, Vineet Menachery

Microbiology And Immunology

Research output: Contribution to journal › Review article

15 Scopus citations

Abstract

Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

Original language	English (US)
Journal	Viruses
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/v11010074
State	Published - Jan 17 2019

Keywords

animal models
coronavirus spike glycoprotein
correlates of immunity
Middle East respiratory syndrome coronavirus
severe acute respiratory syndrome coronavirus
vaccine platforms

ASJC Scopus subject areas

Infectious Diseases
Virology

Access to Document

10.3390/v11010074

Fingerprint Dive into the research topics of 'Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism'. Together they form a unique fingerprint.

Cite this

Schindewolf, C., & Menachery, V. (2019). Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism. Viruses, 11(1). https://doi.org/10.3390/v11010074

@article{a06ec8f7e7ca438a8b855d96af15a9d9,

title = "Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism",

abstract = "Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.",

keywords = "animal models, coronavirus spike glycoprotein, correlates of immunity, Middle East respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus, vaccine platforms",

author = "Craig Schindewolf and Vineet Menachery",

year = "2019",

month = jan,

day = "17",

doi = "10.3390/v11010074",

language = "English (US)",

volume = "11",

journal = "Viruses",

issn = "1999-4915",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

}

TY - JOUR

T1 - Middle East Respiratory Syndrome Vaccine Candidates

T2 - Cautious Optimism

AU - Schindewolf, Craig

AU - Menachery, Vineet

PY - 2019/1/17

Y1 - 2019/1/17

N2 - Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

AB - Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

KW - animal models

KW - coronavirus spike glycoprotein

KW - correlates of immunity

KW - Middle East respiratory syndrome coronavirus

KW - severe acute respiratory syndrome coronavirus

KW - vaccine platforms

UR - http://www.scopus.com/inward/record.url?scp=85060124569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060124569&partnerID=8YFLogxK

U2 - 10.3390/v11010074

DO - 10.3390/v11010074

M3 - Review article

C2 - 30658390

AN - SCOPUS:85060124569

VL - 11

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 1

ER -