Middle east respiratory syndrome vaccine candidates: Cautious optimism

Craig Schindewolf; Vineet D. Menachery

doi:10.3390/v11010074

Middle east respiratory syndrome vaccine candidates: Cautious optimism

Craig Schindewolf, Vineet D. Menachery

Microbiology And Immunology

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

Original language	English (US)
Article number	74
Journal	Viruses
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/v11010074
State	Published - Jan 1 2019

Keywords

Animal models
Coronavirus spike glycoprotein
Correlates of immunity
Middle East respiratory syndrome coronavirus
Severe acute respiratory syndrome coronavirus
Vaccine platforms

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v11010074

Cite this

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abstract = "Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.",

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author = "Craig Schindewolf and Menachery, {Vineet D.}",

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AB - Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

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KW - Correlates of immunity

KW - Middle East respiratory syndrome coronavirus

KW - Severe acute respiratory syndrome coronavirus

KW - Vaccine platforms

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Middle east respiratory syndrome vaccine candidates: Cautious optimism

Abstract

Keywords

ASJC Scopus subject areas

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