Milk- and soy protein-induced enterocolitis

Evidence for lymphocyte sensitization to specific food proteins

Greggory J. Van Sickle, Geraldine Keating Powell, Phillip J. McDonald, Randall M. Goldblum

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Stimulation ([3H]thymidine incorporation) of blood lymphocytes cultured with food proteins was evaluated in infants with food protein-induced enterocolitis and correlated with the results of oral diagnostic challenges with the same foods (soy, cow's milk, and egg white). The geometric mean stimulation index for lymphocytes from patients with positive oral soy protein challenge that were cultured with soy protein was 8.5, and for patients with positive cow's milk challenge the stimulation index was 6.0 when casein was used in the cultures. Both values are significantly different from the values obtained from patients with negative oral challenges (p < 0.01). The enhanced lymphocyte responses were specific for the food proteins responsible for clinical symptoms. It is not clear whether these lymphocyte responses are due to systemic immunization secondary to macromolecular absorption, or to an abnormality in immune regulation such as a delay in the development of oral tolerance mechanisms. They suggest, however, that circulating lymphocytes sensitive to the food antigens that produce the clinical symptoms are frequent in infants with this discrete form of food protein hypersensitivity.

Original languageEnglish (US)
Pages (from-to)1915-1921
Number of pages7
JournalGastroenterology
Volume88
Issue number6
StatePublished - 1985

Fingerprint

Enterocolitis
Soybean Proteins
Milk Proteins
Lymphocytes
Food
Proteins
Soy Milk
Infant Food
Secondary Immunization
Egg White
Food Hypersensitivity
Lymphocyte Activation
Caseins
Thymidine
Milk
Antigens

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Van Sickle, G. J., Powell, G. K., McDonald, P. J., & Goldblum, R. M. (1985). Milk- and soy protein-induced enterocolitis: Evidence for lymphocyte sensitization to specific food proteins. Gastroenterology, 88(6), 1915-1921.

Milk- and soy protein-induced enterocolitis : Evidence for lymphocyte sensitization to specific food proteins. / Van Sickle, Greggory J.; Powell, Geraldine Keating; McDonald, Phillip J.; Goldblum, Randall M.

In: Gastroenterology, Vol. 88, No. 6, 1985, p. 1915-1921.

Research output: Contribution to journalArticle

Van Sickle, GJ, Powell, GK, McDonald, PJ & Goldblum, RM 1985, 'Milk- and soy protein-induced enterocolitis: Evidence for lymphocyte sensitization to specific food proteins', Gastroenterology, vol. 88, no. 6, pp. 1915-1921.
Van Sickle, Greggory J. ; Powell, Geraldine Keating ; McDonald, Phillip J. ; Goldblum, Randall M. / Milk- and soy protein-induced enterocolitis : Evidence for lymphocyte sensitization to specific food proteins. In: Gastroenterology. 1985 ; Vol. 88, No. 6. pp. 1915-1921.
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