TY - JOUR
T1 - Milk protein quantity and quality in low-birth-weight infants. IV. Effects on tyrosine and phenylalanine in plasma and urine
AU - Rassin, David K.
AU - Gaull, Gerald E.
AU - Räihä, Neils C.R.
AU - Heinonen, Kirsti
N1 - Funding Information:
From the Department of Pediatric Research, New York State Institute for Basic Research in Mental Retardation, and Mount Sinai School of Medicine of the City University of New York, and the Children's Hospital, University of Hetsinki. Supported in part by Wyeth Laboratories, the Juselius Foundation, and the New York State Department of Mental Hygiene. *Reprint address: Department of Pediatric Research', N.Y.S. Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, Staten .Island, NY 10314.
PY - 1977/3
Y1 - 1977/3
N2 - Well, appropriate-for-gestational age, low-birth-weight infants were divided into three gestational agegroups and assigned randomly within each age group to one of five feeding regimens: pooled human milk (BM); formula 1 (F1)=1.5 gm/dl protein, 60 parts bovine whey proteins: 40 parts bovine caseins; F2=3.0 gm/dl, 60:40; F3=1.5 gm/dl, 18:82; F4=3.0 gm/dl, 18:82. Plasma and urine concentrations of tyrosine and phenylalanine were far higher in the infants fed F1 to F4, especially F2 and F4, than in the infants fed BM. These findings offer further evidence for the limited capacity of the low-birth-weight infant to catabolize tyrosine. Infants fed F3 had significantly higher plasma tyrosine concentrations than infants fed F1, and those fed F4 had higher concentrations than those fed F2. Thus, increased plasma tyrosine concentrations in low-birth-weight infants are related directly both to the quantity and to the quality of the protein in their diets.
AB - Well, appropriate-for-gestational age, low-birth-weight infants were divided into three gestational agegroups and assigned randomly within each age group to one of five feeding regimens: pooled human milk (BM); formula 1 (F1)=1.5 gm/dl protein, 60 parts bovine whey proteins: 40 parts bovine caseins; F2=3.0 gm/dl, 60:40; F3=1.5 gm/dl, 18:82; F4=3.0 gm/dl, 18:82. Plasma and urine concentrations of tyrosine and phenylalanine were far higher in the infants fed F1 to F4, especially F2 and F4, than in the infants fed BM. These findings offer further evidence for the limited capacity of the low-birth-weight infant to catabolize tyrosine. Infants fed F3 had significantly higher plasma tyrosine concentrations than infants fed F1, and those fed F4 had higher concentrations than those fed F2. Thus, increased plasma tyrosine concentrations in low-birth-weight infants are related directly both to the quantity and to the quality of the protein in their diets.
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U2 - 10.1016/S0022-3476(77)80693-8
DO - 10.1016/S0022-3476(77)80693-8
M3 - Article
C2 - 839327
AN - SCOPUS:0017346785
SN - 0022-3476
VL - 90
SP - 356
EP - 360
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 3
ER -