Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: How much is enough?

Douglas G. Burrin, Barbara Stoll, Ruhong Jiang, Xiaoyan Chang, Bolette Hartmann, Jens Juul Holst, George H. Greeley, Peter J. Reeds

    Research output: Contribution to journalArticle

    173 Scopus citations

    Abstract

    Background: Parenterally nourished preterm infants commonly receive minimal enteral feedings, the aim being to enhance intestinal function. Whether this regimen increases intestinal growth has not been established. Objective: Our objective was to determine the minimal enteral nutrient intakes necessary to stimulate and to normalize neonatal intestinal growth. Methods: Intestinal growth and cell proliferation were quantified in neonatal pigs given equal amounts of an elemental nutrient solution for 7 d. Different groups (n = 5-7 per group) received 0%, 10%, 20%, 40%, 60%, 80%, or 100% of total nutrient intake enterally, with the remainder given parenterally. Results: In the jejunum, wet weight, protein mass, and villus height were significantly greater at enteral intakes >40%. Stimulation of ileal protein mass required a higher enteral intake (60%). In both segments, abrupt increases in DNA mass, crypt depth, ornithine decarboxylase activity, and crypt cells in S-phase occurred between enteral intakes of 40% and 60%. Circulating concentrations of glucagon-like peptide-2 and peptide YY, but not gastrin, increased significantly between enteral intakes of 40% and 60% and closely paralleled indexes of cell proliferation Conclusions: The minimal enteral nutrient intake necessary to increase mucosal mass was 40% of total nutrient intake, whereas 60% enteral nutrition was necessary to sustain normal mucosal proliferation and growth. Our results imply that providing <40% of the total nutrient intake enterally does not have significant intestinal trophic effects.

    Original languageEnglish (US)
    Pages (from-to)1603-1610
    Number of pages8
    JournalAmerican Journal of Clinical Nutrition
    Volume71
    Issue number6
    DOIs
    StatePublished - Jun 2000

    Keywords

    • Cell proliferation
    • Enteral nutrition
    • GLP-2
    • Glucagon-like peptide-2
    • Low-birth-weight infants
    • Minimal enteral feeding
    • Neonatal nutrition
    • Neonatology
    • PYY
    • Peptide YY
    • Premature infants
    • Preterm infants
    • Total parenteral nutrition

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

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  • Cite this

    Burrin, D. G., Stoll, B., Jiang, R., Chang, X., Hartmann, B., Holst, J. J., Greeley, G. H., & Reeds, P. J. (2000). Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: How much is enough? American Journal of Clinical Nutrition, 71(6), 1603-1610. https://doi.org/10.1093/ajcn/71.6.1603