Mitochondrial disorders in chagasic cardiomyopathy.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The mitochondria play a complex multi-factorial role in the cell. Along with their primary role in energy (ATP) production, mitochondria generate reactive oxygen species (ROS) that directly or indirectly affect several cellular functions. In this article, I review the molecular, structural and functional mitochondrial abnormalities reported in chagasic cardiomyopathy. I highlight current information about the potential etiology and the pathophysiological significance of mitochondrial dysfunction in chagasic cardiomyopathy and provide a brief background of mitochondrial biogenesis and bioenergetic pathways in cardiac growth and development.

Original languageEnglish (US)
Pages (from-to)1341-1354
Number of pages14
JournalFrontiers in bioscience : a journal and virtual library
Volume10
StatePublished - 2005

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Mitochondrial Diseases
Mitochondria
Cardiomyopathies
Organelle Biogenesis
Growth and Development
Energy Metabolism
Reactive Oxygen Species
Adenosine Triphosphate

Cite this

Mitochondrial disorders in chagasic cardiomyopathy. / Garg, Nisha.

In: Frontiers in bioscience : a journal and virtual library, Vol. 10, 2005, p. 1341-1354.

Research output: Contribution to journalArticle

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