Mitochondrial DNA haplogroups and neurocognitive impairment during HIV infection

Todd Hulgan, David C. Samuels, William Bush, Ronald J. Ellis, Scott L. Letendre, Robert K. Heaton, Donald R. Franklin, Peter Straub, Deborah G. Murdock, David B. Clifford, Ann C. Collier, Benjamin Gelman, Christina M. Marra, Justin C. Mcarthur, J. Allen Mccutchan, Susan Morgello, David M. Simpson, Igor Grant, Asha R. Kallianpur

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background.Neurocognitive impairment (NCI) remains an important complication in persons infected with human immunodeficiency virus (HIV). Ancestry-related mitochondrial DNA (mtDNA) haplogroups have been associated with outcomes of HIV infection and combination antiretroviral therapy (CART), and with neurodegenerative diseases. We hypothesize that mtDNA haplogroups are associated with NCI in HIV-infected adults and performed a genetic association study in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) cohort. Methods.CHARTER is an observational study of ambulatory HIV-infected adults. Haplogroups were assigned using mtDNA sequence, and principal components were derived from ancestry-informative nuclear DNA variants. Outcomes were cross-sectional global deficit score (GDS) as a continuous measure, GDS impairment (GDS ≥ 0.50), and HIV-associated neurocognitive disorder (HAND) using international criteria. Multivariable models were adjusted for comorbidity status (incidental vs contributing), current CART, plasma HIV RNA, reading ability, and CD4 cell nadir. Results.Haplogroups were available from 1027 persons; median age 43 years, median CD4 nadir 178 cells/mm3, 72% on CART, and 46% with HAND. The 102 (9.9%) persons of genetically determined admixed Hispanic ancestry had more impairment by GDS or HAND than persons of European or African ancestry (P

Original languageEnglish (US)
Pages (from-to)1476-1484
Number of pages9
JournalClinical Infectious Diseases
Volume61
Issue number9
DOIs
StatePublished - Nov 1 2015

Fingerprint

Virus Diseases
Mitochondrial DNA
HIV
Therapeutics
Cohort Effect
Aptitude
Genetic Association Studies
Hispanic Americans
Research
Neurodegenerative Diseases
Observational Studies
Comorbidity
Reading
RNA
DNA

Keywords

  • AIDS
  • cognitive disorders
  • DNA, mitochondrial
  • HIV

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Hulgan, T., Samuels, D. C., Bush, W., Ellis, R. J., Letendre, S. L., Heaton, R. K., ... Kallianpur, A. R. (2015). Mitochondrial DNA haplogroups and neurocognitive impairment during HIV infection. Clinical Infectious Diseases, 61(9), 1476-1484. https://doi.org/10.1093/cid/civ527

Mitochondrial DNA haplogroups and neurocognitive impairment during HIV infection. / Hulgan, Todd; Samuels, David C.; Bush, William; Ellis, Ronald J.; Letendre, Scott L.; Heaton, Robert K.; Franklin, Donald R.; Straub, Peter; Murdock, Deborah G.; Clifford, David B.; Collier, Ann C.; Gelman, Benjamin; Marra, Christina M.; Mcarthur, Justin C.; Mccutchan, J. Allen; Morgello, Susan; Simpson, David M.; Grant, Igor; Kallianpur, Asha R.

In: Clinical Infectious Diseases, Vol. 61, No. 9, 01.11.2015, p. 1476-1484.

Research output: Contribution to journalArticle

Hulgan, T, Samuels, DC, Bush, W, Ellis, RJ, Letendre, SL, Heaton, RK, Franklin, DR, Straub, P, Murdock, DG, Clifford, DB, Collier, AC, Gelman, B, Marra, CM, Mcarthur, JC, Mccutchan, JA, Morgello, S, Simpson, DM, Grant, I & Kallianpur, AR 2015, 'Mitochondrial DNA haplogroups and neurocognitive impairment during HIV infection', Clinical Infectious Diseases, vol. 61, no. 9, pp. 1476-1484. https://doi.org/10.1093/cid/civ527
Hulgan T, Samuels DC, Bush W, Ellis RJ, Letendre SL, Heaton RK et al. Mitochondrial DNA haplogroups and neurocognitive impairment during HIV infection. Clinical Infectious Diseases. 2015 Nov 1;61(9):1476-1484. https://doi.org/10.1093/cid/civ527
Hulgan, Todd ; Samuels, David C. ; Bush, William ; Ellis, Ronald J. ; Letendre, Scott L. ; Heaton, Robert K. ; Franklin, Donald R. ; Straub, Peter ; Murdock, Deborah G. ; Clifford, David B. ; Collier, Ann C. ; Gelman, Benjamin ; Marra, Christina M. ; Mcarthur, Justin C. ; Mccutchan, J. Allen ; Morgello, Susan ; Simpson, David M. ; Grant, Igor ; Kallianpur, Asha R. / Mitochondrial DNA haplogroups and neurocognitive impairment during HIV infection. In: Clinical Infectious Diseases. 2015 ; Vol. 61, No. 9. pp. 1476-1484.
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AU - Samuels, David C.

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AU - Heaton, Robert K.

AU - Franklin, Donald R.

AU - Straub, Peter

AU - Murdock, Deborah G.

AU - Clifford, David B.

AU - Collier, Ann C.

AU - Gelman, Benjamin

AU - Marra, Christina M.

AU - Mcarthur, Justin C.

AU - Mccutchan, J. Allen

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AU - Grant, Igor

AU - Kallianpur, Asha R.

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