Mitochondrial poly(ADP-ribose) polymerase

The Wizard of Oz at work

Attila Brunyanszki, Bartosz Szczesny, László Virág, Csaba Szabo

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Among multiple members of the poly(ADP-ribose) polymerase (PARP) family, PARP1 accounts for the majority of PARP activity in mammalian cells. Although PARP1 is predominantly localized to the nucleus, and its nuclear regulatory roles are most commonly studied and are the best characterized, several lines of data demonstrate that PARP1 is also present in the mitochondria, and suggest that mitochondrial PARP (mtPARP) plays an important role in the regulation of various cellular functions in health and disease. The goal of the current article is to review the experimental evidence for the mitochondrial localization of PARP1 and its intra-mitochondrial functions, with focus on cellular bioenergetics, mitochondrial DNA repair and mitochondrial dysfunction. In addition, we also propose a working model for the interaction of mitochondrial and nuclear PARP during oxidant-induced cell death. MtPARP is similar to the Wizard of Oz in the sense that it is enigmatic, it has been elusive for a long time and it remains difficult to be interrogated. mtPARP - at least in some cell types - works incessantly "behind the curtains" as an orchestrator of many important cellular functions.

    Original languageEnglish (US)
    JournalFree Radical Biology and Medicine
    DOIs
    StateAccepted/In press - Dec 15 2015

    Fingerprint

    Poly(ADP-ribose) Polymerases
    Mitochondria
    Cell death
    Mitochondrial DNA
    Oxidants
    DNA Repair
    Energy Metabolism
    Repair
    Cell Death
    Cells
    Health

    Keywords

    • Cell death
    • Mitochondria
    • Oxidative stress
    • PARP
    • Poly(ADP-ribose)

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology (medical)

    Cite this

    Mitochondrial poly(ADP-ribose) polymerase : The Wizard of Oz at work. / Brunyanszki, Attila; Szczesny, Bartosz; Virág, László; Szabo, Csaba.

    In: Free Radical Biology and Medicine, 15.12.2015.

    Research output: Contribution to journalArticle

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