Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes

Ruth Noriega-Cisneros, Christian Cortés-Rojo, Salvador Manzo-Avalos, Mónica Clemente-Guerrero, Elizabeth Calderón-Cortés, Rafael Salgado-Garciglia, Rocío Montoya-Pérez, Istvan Boldogh, Alfredo Saavedra-Molina

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Diabetes mellitus (DM) is associated with increased production of reactive oxygen and nitrogen species; consequently, an increase in lipid peroxidation and a decrease in antioxidants resulting in mitochondrial dysfunction. Using a rat model of DM induced by streptozotocin, we show the opposite: an increase in NO levels, S-nitrosylation, aconitase activity, and total glutathione and a decrease in lipid peroxidation at early stages of diabetes. These data imply that the decrease in lipid peroxidation is a vital early response to hyperglycemia to prevent escalation of ROS generation in mitochondria. These results also suggest a need for novel therapeutic targets to prevent the neurological consequences of diabetes.

Original languageEnglish
Pages (from-to)835-840
Number of pages6
JournalMitochondrion
Volume13
Issue number6
DOIs
StatePublished - Nov 2013

Fingerprint

Lipid Peroxidation
Oxidative Stress
Diabetes Mellitus
Aconitate Hydratase
Reactive Nitrogen Species
Streptozocin
Hyperglycemia
Glutathione
Reactive Oxygen Species
Mitochondria
Antioxidants
Therapeutics

Keywords

  • Antioxidant
  • Brain mitochondria
  • Diabetes
  • Glutathione
  • Nitrosative stress
  • Oxidative stress

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine

Cite this

Noriega-Cisneros, R., Cortés-Rojo, C., Manzo-Avalos, S., Clemente-Guerrero, M., Calderón-Cortés, E., Salgado-Garciglia, R., ... Saavedra-Molina, A. (2013). Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes. Mitochondrion, 13(6), 835-840. https://doi.org/10.1016/j.mito.2013.05.012

Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes. / Noriega-Cisneros, Ruth; Cortés-Rojo, Christian; Manzo-Avalos, Salvador; Clemente-Guerrero, Mónica; Calderón-Cortés, Elizabeth; Salgado-Garciglia, Rafael; Montoya-Pérez, Rocío; Boldogh, Istvan; Saavedra-Molina, Alfredo.

In: Mitochondrion, Vol. 13, No. 6, 11.2013, p. 835-840.

Research output: Contribution to journalArticle

Noriega-Cisneros, R, Cortés-Rojo, C, Manzo-Avalos, S, Clemente-Guerrero, M, Calderón-Cortés, E, Salgado-Garciglia, R, Montoya-Pérez, R, Boldogh, I & Saavedra-Molina, A 2013, 'Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes', Mitochondrion, vol. 13, no. 6, pp. 835-840. https://doi.org/10.1016/j.mito.2013.05.012
Noriega-Cisneros R, Cortés-Rojo C, Manzo-Avalos S, Clemente-Guerrero M, Calderón-Cortés E, Salgado-Garciglia R et al. Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes. Mitochondrion. 2013 Nov;13(6):835-840. https://doi.org/10.1016/j.mito.2013.05.012
Noriega-Cisneros, Ruth ; Cortés-Rojo, Christian ; Manzo-Avalos, Salvador ; Clemente-Guerrero, Mónica ; Calderón-Cortés, Elizabeth ; Salgado-Garciglia, Rafael ; Montoya-Pérez, Rocío ; Boldogh, Istvan ; Saavedra-Molina, Alfredo. / Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes. In: Mitochondrion. 2013 ; Vol. 13, No. 6. pp. 835-840.
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