Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes

Ruth Noriega-Cisneros, Christian Cortés-Rojo, Salvador Manzo-Avalos, Mónica Clemente-Guerrero, Elizabeth Calderón-Cortés, Rafael Salgado-Garciglia, Rocío Montoya-Pérez, Istvan Boldogh, Alfredo Saavedra-Molina

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Diabetes mellitus (DM) is associated with increased production of reactive oxygen and nitrogen species; consequently, an increase in lipid peroxidation and a decrease in antioxidants resulting in mitochondrial dysfunction. Using a rat model of DM induced by streptozotocin, we show the opposite: an increase in NO levels, S-nitrosylation, aconitase activity, and total glutathione and a decrease in lipid peroxidation at early stages of diabetes. These data imply that the decrease in lipid peroxidation is a vital early response to hyperglycemia to prevent escalation of ROS generation in mitochondria. These results also suggest a need for novel therapeutic targets to prevent the neurological consequences of diabetes.

Original languageEnglish (US)
Pages (from-to)835-840
Number of pages6
JournalMitochondrion
Volume13
Issue number6
DOIs
StatePublished - Nov 1 2013

Keywords

  • Antioxidant
  • Brain mitochondria
  • Diabetes
  • Glutathione
  • Nitrosative stress
  • Oxidative stress

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine

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    Noriega-Cisneros, R., Cortés-Rojo, C., Manzo-Avalos, S., Clemente-Guerrero, M., Calderón-Cortés, E., Salgado-Garciglia, R., Montoya-Pérez, R., Boldogh, I., & Saavedra-Molina, A. (2013). Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes. Mitochondrion, 13(6), 835-840. https://doi.org/10.1016/j.mito.2013.05.012