Mitochondrial thioredoxin in regulation of oxidant-induced cell death

Yan Chen, Jiyang Cai, Dean P. Jones

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Mitochondrial thioredoxin (mtTrx) can be oxidized in response to inducers of oxidative stress; yet the functional consequences of the oxidation have not been determined. This study evaluated the redox status of mtTrx and its association to oxidant-induced apoptosis. Results showed that mtTrx was oxidized after exposure to peroxides and diamide. Overexpression of mtTrx protected against diamide-induced oxidation and cytotoxicity. Oxidation of mtTrx was also achieved by knocking down its reductase; and lead to increased susceptibility to cell death. The data indicate that the redox status of mtTrx is a regulatory mechanism underlying the vulnerability of mitochondria to oxidative injury.

Original languageEnglish (US)
Pages (from-to)6596-6602
Number of pages7
JournalFEBS Letters
Volume580
Issue number28-29
DOIs
StatePublished - Dec 11 2006
Externally publishedYes

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Keywords

  • Mitochondria
  • Oxidative stress
  • Redox
  • Thioredoxin
  • Thioredoxin reductase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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