Mitochondriopathy of peripheral arterial disease

Konstantinos I. Makris, Aikaterini A. Nella, Zhen Zhu, Stanley A. Swanson, George P. Casale, Tanuja L. Gutti, Andrew R. Judge, Iraklis I. Pipinos

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The signs and symptoms of peripheral arterial occlusive disease (PAD), including claudication, rest pain, and tissue loss, are consequences of compromised bioenergetics and oxidative tissue injury within the affected lower extremities. Compromised bioenergetics is the result of a combination of low blood flow through diseased arteries and diminished adenosine triphosphate production by dysfunctional mitochondria. The tissue injury appears to be secondary to increased production of reactive oxygen species by dysfunctional mitochondria and by inflammation, in association with ischemia and ischemia/reperfusion. In this review, we present the current histomorphologic, physiologic, and biochemical evidence defining the nature of this mitochondriopathy and discuss its contribution to the pathogenesis and clinical manifestations of PAD.

Original languageEnglish (US)
Pages (from-to)336-343
Number of pages8
JournalVascular
Volume15
Issue number6
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

Arterial Occlusive Diseases
Peripheral Arterial Disease
Energy Metabolism
Mitochondria
Ischemia
Nociceptive Pain
Wounds and Injuries
Signs and Symptoms
Reperfusion
Lower Extremity
Reactive Oxygen Species
Arteries
Adenosine Triphosphate
Inflammation

Keywords

  • Claudication
  • Energy metabolism
  • Ischemia
  • Mitochondria
  • Oxidative stress
  • Peripheral arterial disease
  • Skeletal muscle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Makris, K. I., Nella, A. A., Zhu, Z., Swanson, S. A., Casale, G. P., Gutti, T. L., ... Pipinos, I. I. (2007). Mitochondriopathy of peripheral arterial disease. Vascular, 15(6), 336-343. https://doi.org/10.2310/6670.2007.00054

Mitochondriopathy of peripheral arterial disease. / Makris, Konstantinos I.; Nella, Aikaterini A.; Zhu, Zhen; Swanson, Stanley A.; Casale, George P.; Gutti, Tanuja L.; Judge, Andrew R.; Pipinos, Iraklis I.

In: Vascular, Vol. 15, No. 6, 11.2007, p. 336-343.

Research output: Contribution to journalArticle

Makris, KI, Nella, AA, Zhu, Z, Swanson, SA, Casale, GP, Gutti, TL, Judge, AR & Pipinos, II 2007, 'Mitochondriopathy of peripheral arterial disease', Vascular, vol. 15, no. 6, pp. 336-343. https://doi.org/10.2310/6670.2007.00054
Makris KI, Nella AA, Zhu Z, Swanson SA, Casale GP, Gutti TL et al. Mitochondriopathy of peripheral arterial disease. Vascular. 2007 Nov;15(6):336-343. https://doi.org/10.2310/6670.2007.00054
Makris, Konstantinos I. ; Nella, Aikaterini A. ; Zhu, Zhen ; Swanson, Stanley A. ; Casale, George P. ; Gutti, Tanuja L. ; Judge, Andrew R. ; Pipinos, Iraklis I. / Mitochondriopathy of peripheral arterial disease. In: Vascular. 2007 ; Vol. 15, No. 6. pp. 336-343.
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