Mitogen-activated protein kinase signaling is essential for activity-dependent dendritic protein synthesis

Ruomu Gong, Shao Jun Tang

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations

    Abstract

    The expression of long-lasting synaptic plasticity requires synthesis of new proteins. A critical locus for protein synthesis to support synaptic plasticity is the dendrites. Previous studies demonstrate that synaptic activity activates dendritic protein synthesis. The mechanism by which synaptic activity stimulates protein synthesis in dendrites is, however, poorly understood. This study is to determine the role of the mitogen-activated protein kinase signaling pathway in activity-dependent dendritic protein synthesis. Using a green fluorescent protein reporter with CaMKII 5′ and 3′ untranslated regions, we show that dendritic synthesis of the green fluorescent protein induced by N-methyl-D-aspartate stimulation is abolished by U0126, a specific inhibitor of mitogen-activated protein kinase signaling. Our results suggest an important role of the mitogen-activated protein kinase signaling in dendritic protein synthesis induced by N-methyl-D-aspartate receptor activation.

    Original languageEnglish (US)
    Pages (from-to)1575-1578
    Number of pages4
    JournalNeuroReport
    Volume17
    Issue number15
    DOIs
    StatePublished - Oct 2006

    Keywords

    • CaMKII
    • Dendrites
    • Green fluorescent protein
    • Mitogen-activated protein kinase
    • N-methyl-D-aspartate receptors
    • Protein synthesis
    • Synapse
    • Synaptic plasticity
    • Translation
    • mRNA

    ASJC Scopus subject areas

    • General Neuroscience

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