Mitogen-activated protein kinase signaling is essential for activity-dependent dendritic protein synthesis

Ruomu Gong, Shao-Jun Tang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The expression of long-lasting synaptic plasticity requires synthesis of new proteins. A critical locus for protein synthesis to support synaptic plasticity is the dendrites. Previous studies demonstrate that synaptic activity activates dendritic protein synthesis. The mechanism by which synaptic activity stimulates protein synthesis in dendrites is, however, poorly understood. This study is to determine the role of the mitogen-activated protein kinase signaling pathway in activity-dependent dendritic protein synthesis. Using a green fluorescent protein reporter with CaMKII 5′ and 3′ untranslated regions, we show that dendritic synthesis of the green fluorescent protein induced by N-methyl-D-aspartate stimulation is abolished by U0126, a specific inhibitor of mitogen-activated protein kinase signaling. Our results suggest an important role of the mitogen-activated protein kinase signaling in dendritic protein synthesis induced by N-methyl-D-aspartate receptor activation.

Original languageEnglish (US)
Pages (from-to)1575-1578
Number of pages4
JournalNeuroReport
Volume17
Issue number15
DOIs
StatePublished - Oct 2006
Externally publishedYes

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Mitogen-Activated Protein Kinases
Proteins
Neuronal Plasticity
Dendrites
Green Fluorescent Proteins
Calcium-Calmodulin-Dependent Protein Kinase Type 2
5' Untranslated Regions
3' Untranslated Regions
N-Methylaspartate
N-Methyl-D-Aspartate Receptors

Keywords

  • CaMKII
  • Dendrites
  • Green fluorescent protein
  • Mitogen-activated protein kinase
  • mRNA
  • N-methyl-D-aspartate receptors
  • Protein synthesis
  • Synapse
  • Synaptic plasticity
  • Translation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mitogen-activated protein kinase signaling is essential for activity-dependent dendritic protein synthesis. / Gong, Ruomu; Tang, Shao-Jun.

In: NeuroReport, Vol. 17, No. 15, 10.2006, p. 1575-1578.

Research output: Contribution to journalArticle

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