Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks

Keyphrases

• Epithelial-mesenchymal Transition 100%
• Signaling Network 100%
• Mixed-effects Model 100%
• Heat Shock Protein 27 (HSP27) 44%
• Phosphoprotein 22%
• P38 Mitogen-activated Protein Kinase (p38 MAPK) 11%
• Chronic Obstructive Pulmonary Disease 11%
• Glycogen Synthase Kinase 3 (GSK3) 11%
• Airway Remodeling 11%
• Therapeutic Target 11%
• Human Small Airway Epithelial Cells 11%
• Cell State 11%
• Mena 11%
• Transition State 11%
• Signal Transducer and Activator of Transcription 3 11%
• Protein Response 11%
• Strong Coupling 11%
• Asthma Severity 11%
• Normal Phenotype 11%
• System Effects 11%
• Protein Substrate 11%
• Menadione 11%
• Signal Data 11%
• Respiratory mucosa 11%
• Airway Fibrosis 11%
• Decapentaplegic 11%
• Small Body Size 11%
• Computational Model 11%
• Phosphoprotein Signaling 11%
• Topology Map 11%
• Kinase-independent 11%
• Network Topology 11%

Pharmacology, Toxicology and Pharmaceutical Science

• Heat Shock Protein 27 100%
• Phosphoprotein 75%
• Tumor Necrosis Factor 50%
• Fibrosis 25%
• Mitogen Activated Protein Kinase P38 25%
• Chronic Obstructive Lung Disease 25%
• Asthma 25%
• Glycogen Synthase Kinase 3 25%
• STAT3 Protein 25%
• Menadione 25%

Biochemistry, Genetics and Molecular Biology

• Mesenchymal-Epithelial Transition 100%
• Phosphoprotein 33%
• Tumor Necrosis Factor 22%
• STAT3 22%
• Gene Linkage 11%
• Respiratory Mucosa 11%
• Downregulation 11%
• Glycogen Synthase Kinase 3 11%
• Heat Shock Protein 11%
• Signaling Protein 11%
• Body Size 11%
• Mothers against Decapentaplegic 11%
• P38 Mitogen-Activated Protein Kinases 11%
• Menadione 11%