Model for aging in the basal forebrain cholinergic system

Zezong Gu, Gitta Wortwein, Juan Yu, J. Regino Perez-Polo

    Research output: Contribution to journalReview articlepeer-review

    15 Scopus citations


    A key component of the cognitive deficits associated with aging is the loss of function of cholinergic neurons in the basal forebrain due to neuronal losses and decreased cholinergic function of spared neurons. A model to mimic one aspect of this phenomenon is to kill cholinergic neurons selectively in the basal forebrain via administration of the immunotoxin IgG-192-saporin. Here we discuss apoptotic regulators, such as nerve growth factor, in age-associated changes present in the cholinergic system and the role of the NF-κB signaling system in cellular commitment to apoptosis. We also examine the age-associated decline in intrinsic response mechanisms, which may account for the age-associated reduction in recovery from both acute and chronic insults to the central nervous system.

    Original languageEnglish (US)
    Pages (from-to)437-447
    Number of pages11
    JournalAntioxidants and Redox Signaling
    Issue number3
    StatePublished - 2000

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Molecular Biology
    • Clinical Biochemistry
    • Cell Biology


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