Model of HIV-1 disease progression based on virus-induced lymph node homing and homing-induced apoptosis of CD4+ lymphocytes

Denise Kirschner, G. F. Webb, Miles Cloyd

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Several proposed theories have described the progression of HIV infection. Even so, no concrete evidence supports any as comprehensive, including, for example, why the CD4+ T-cell counts fall from 1000/mm3 of blood to roughly 100/mm3 over an average 10-year period, whereas concomitant viral loads are relatively constant, increasing by several orders of magnitude in late-stage disease. Here, we develop and validate a theoretical model that altered lymphocyte circulation patterns between the lymph system and blood due to HIV-induced enhanced lymph-node homing and subsequent apoptosis of resting CD4+ T cells can explain many aspects of HIV-1 disease progression. These results lead to a recalculation of the CD4+ lymphocyte dynamics during highly active antiretroviral therapy, and also suggest new targets for therapy.

Original languageEnglish (US)
Pages (from-to)352-362
Number of pages11
JournalJournal of Acquired Immune Deficiency Syndromes
Volume24
Issue number4
DOIs
StatePublished - Aug 1 2000

Keywords

  • Apoptosis
  • HIV
  • Homing
  • Lymphocytes
  • Mathematical model

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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