Modeling analysis of change in neurologic abnormalities in children born prematurely: A novel approach

Anne Anderson, Paul Swank, Susan Wildin, Susan Landry, Karen Smith

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The purpose of this longitudinal study was to evaluate changes in neurologic abnormalities in 212 preterm and 128 full-term children. Preterm infants with severe medical complications were considered at high risk, while those with milder complications were considered at low risk for neurodevelopmental abnormality. The patterns of change in neurologic status for the high- and low-risk preterm and term groups across 6, 12, 24, 40, and 54 months of age were compared using growth modeling analysis. As expected, the term group showed minimal change, while the two preterm groups demonstrated complex, nonlinear patterns of change in neurologic abnormalities. While the results demonstrate improvement over time in both groups of preterm infants, 35% of the children in the high-risk group had neurologic scores in the borderline or abnormal range at 54 months. These findings demonstrate that neurologic deficits are still evident at preschool age in some preterm children and that these deficits are related to the severity of neonatal complications.

Original languageEnglish (US)
Pages (from-to)502-508
Number of pages7
JournalJournal of Child Neurology
Issue number8
StatePublished - Aug 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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