Modeling of intraluminal heating of biological tissue

Implications for treatment of benign prostatic hyperplasia

B. Anvari, S. Rastegar, Massoud Motamedi

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A computer model for predicting the thermal response of a biological tissue to different intraluminal heating modalities is presented. A practical application of the model is to calculate the temperature distributions during thermal coagulation of prostate by contact heating and radiative heating. The model uses a two-dimensional axisymmetric diffusion approximation method to calculate the light distribution during radiative heating. The traditional Pennes' bio-heat equation is used to calculate the temperatures in the presence of blood flow. An implicit finite difference scheme with nonuniform grid spacings is used to solve the diffusion equation for light distribution and the bio-heat equation. Model results indicate that the radiative heating of prostate by Nd:YAG (1064 mm) and diode (810 mm) lasers can be a more effective and efficient means of coagulating a large volume of prostate, as compared to contact heating of the tissue. Blood perfusion is shown to provide a considerable heat sink as the laser exposure time is increased. Surface cooling by irrigation during the laser irradiation of tissue is shown to be an effective method for delaying tissue explosion and obtaining a large volume of coagulated tissue. The model also shows that the volume of the coagulated tissue is appreciably altered by a change in the rate of energy deposition.

Original languageEnglish (US)
Pages (from-to)854-864
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Volume41
Issue number9
DOIs
StatePublished - 1994

Fingerprint

Tissue
Heating
Blood
Lasers
Heat sinks
Laser beam effects
Coagulation
Irrigation
Explosions
Diodes
Temperature distribution
Cooling
Hot Temperature
Temperature

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Modeling of intraluminal heating of biological tissue : Implications for treatment of benign prostatic hyperplasia. / Anvari, B.; Rastegar, S.; Motamedi, Massoud.

In: IEEE Transactions on Biomedical Engineering, Vol. 41, No. 9, 1994, p. 854-864.

Research output: Contribution to journalArticle

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