Modelling of human transplacental transport as performed in Copenhagen, Denmark

Line Mathiesen, Thit Aarøe Mørck, Giuseppina Zuri, Maria Helena Andersen, Caroline Pehrson, Marie Frederiksen, Tina Mose, Erik Rytting, Marie S. Poulsen, Jeanette Ks Nielsen, Lisbeth E. Knudsen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Placenta perfusion models are very effective when studying the placental mechanisms in order to extrapolate to real-life situations. The models are most often used to investigate the transport of substances between mother and foetus, including the potential metabolism of these. We have studied the relationships between maternal and foetal exposures to various compounds including pollutants such as polychlorinated biphenyls, polybrominated flame retardants, nanoparticles as well as recombinant human antibodies. The compounds have been studied in the human placenta perfusion model and to some extent in vitro with an established human monolayer trophoblast cell culture model. Results from our studies distinguish placental transport of substances by physicochemical properties, adsorption to placental tissue, binding to transport and receptor proteins and metabolism. We have collected data from different classes of chemicals and nanoparticles for comparisons across chemical structures as well as different test systems. Our test systems are based on human material to bypass the extrapolation from animal data. By combining data from our two test systems, we are able to rank and compare the transport of different classes of substances according to their transport ability. Ultimately, human data including measurements in cord blood contribute to the study of placental transport.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalBasic and Clinical Pharmacology and Toxicology
Volume115
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Denmark
Metabolism
Nanoparticles
Placenta
Flame Retardants
Perfusion
Polychlorinated Biphenyls
Maternal Exposure
Cell culture
Extrapolation
Trophoblasts
Monolayers
Animals
Blood
Fetal Blood
Adsorption
Tissue
Carrier Proteins
Fetus
Cell Culture Techniques

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Medicine(all)

Cite this

Mathiesen, L., Mørck, T. A., Zuri, G., Andersen, M. H., Pehrson, C., Frederiksen, M., ... Knudsen, L. E. (2014). Modelling of human transplacental transport as performed in Copenhagen, Denmark. Basic and Clinical Pharmacology and Toxicology, 115(1), 93-100. https://doi.org/10.1111/bcpt.12228

Modelling of human transplacental transport as performed in Copenhagen, Denmark. / Mathiesen, Line; Mørck, Thit Aarøe; Zuri, Giuseppina; Andersen, Maria Helena; Pehrson, Caroline; Frederiksen, Marie; Mose, Tina; Rytting, Erik; Poulsen, Marie S.; Nielsen, Jeanette Ks; Knudsen, Lisbeth E.

In: Basic and Clinical Pharmacology and Toxicology, Vol. 115, No. 1, 2014, p. 93-100.

Research output: Contribution to journalArticle

Mathiesen, L, Mørck, TA, Zuri, G, Andersen, MH, Pehrson, C, Frederiksen, M, Mose, T, Rytting, E, Poulsen, MS, Nielsen, JK & Knudsen, LE 2014, 'Modelling of human transplacental transport as performed in Copenhagen, Denmark', Basic and Clinical Pharmacology and Toxicology, vol. 115, no. 1, pp. 93-100. https://doi.org/10.1111/bcpt.12228
Mathiesen, Line ; Mørck, Thit Aarøe ; Zuri, Giuseppina ; Andersen, Maria Helena ; Pehrson, Caroline ; Frederiksen, Marie ; Mose, Tina ; Rytting, Erik ; Poulsen, Marie S. ; Nielsen, Jeanette Ks ; Knudsen, Lisbeth E. / Modelling of human transplacental transport as performed in Copenhagen, Denmark. In: Basic and Clinical Pharmacology and Toxicology. 2014 ; Vol. 115, No. 1. pp. 93-100.
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