Abstract
The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorrhagic fever; this is owing to the fact that only humans show signs of disease. In the past 5 years, research has better identified the initial target cells of infection, and this has led to the development of models of infection in primary human cell cultures. Mouse-human chimeras, containing these target cells, have also led to progress in developing animal models. These advances should soon end the stalemate in testing antivirals and vaccine preparations that had necessarily been done in incomplete or irrelevant models.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-103 |
| Number of pages | 7 |
| Journal | Drug Discovery Today: Disease Models |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Drug Discovery
- Molecular Medicine
Cite this
Models of dengue virus infection. / Bente, Dennis; Rico-Hesse, Rebeca.
In: Drug Discovery Today: Disease Models, Vol. 3, No. 1, 2006, p. 97-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Models of dengue virus infection
AU - Bente, Dennis
AU - Rico-Hesse, Rebeca
PY - 2006
Y1 - 2006
N2 - The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorrhagic fever; this is owing to the fact that only humans show signs of disease. In the past 5 years, research has better identified the initial target cells of infection, and this has led to the development of models of infection in primary human cell cultures. Mouse-human chimeras, containing these target cells, have also led to progress in developing animal models. These advances should soon end the stalemate in testing antivirals and vaccine preparations that had necessarily been done in incomplete or irrelevant models.
AB - The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorrhagic fever; this is owing to the fact that only humans show signs of disease. In the past 5 years, research has better identified the initial target cells of infection, and this has led to the development of models of infection in primary human cell cultures. Mouse-human chimeras, containing these target cells, have also led to progress in developing animal models. These advances should soon end the stalemate in testing antivirals and vaccine preparations that had necessarily been done in incomplete or irrelevant models.
UR - http://www.scopus.com/inward/record.url?scp=33645891649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645891649&partnerID=8YFLogxK
U2 - 10.1016/j.ddmod.2006.03.014
DO - 10.1016/j.ddmod.2006.03.014
M3 - Article
VL - 3
SP - 97
EP - 103
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
SN - 1740-6757
IS - 1
ER -