Models of dengue virus infection

Dennis A. Bente, Rebeca Rico-Hesse

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorrhagic fever; this is owing to the fact that only humans show signs of disease. In the past 5 years, research has better identified the initial target cells of infection, and this has led to the development of models of infection in primary human cell cultures. Mouse-human chimeras, containing these target cells, have also led to progress in developing animal models. These advances should soon end the stalemate in testing antivirals and vaccine preparations that had necessarily been done in incomplete or irrelevant models.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalDrug Discovery Today: Disease Models
Volume3
Issue number1
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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