Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans

Elena Volpi, Paola Lucidi, Guido Cruciani, Francesca Monacchia, Stefania Santoni, Gianpaolo Reboldi, Paolo Brunetti, Geremia B. Bolli, Pierpaolo De Feo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The intake of ~70 g of alcohol impairs liver protein metabolism in healthy humans. To establish the threshold at which alcohol impairs hepatic protein metabolism in humans we compared the effects of 500 mL of water (control study), 300 (28.4 g ethanol) or 750 mL (71 g ethanol) of table wine on hepatic protein metabolism in three groups of healthy nonalcoholic volunteers. Hepatic protein metabolism was estimated (L-[1-14C]leucine infusion) by measuring the fractional secretory rates of albumin and fibrinogen during the overnight postabsorptive state (basal) and the subsequent administration of water or two different amounts of wine (300 or 750 mL) given with a liquid glucose-lipid-amino acid meal. During the meal, water did not affect fibrinogen fractional secretory rate and increased albumin fractional secretory rate by ~50% (P < 0.01). The 300 mL of wine increased albumin secretory rate by only ~20% (P < 0.01 vs. basal, P < 0.04 vs. water) and did not affect fibrinogen secretory rate. The 750 mL of wine profoundly impaired hepatic protein metabolism, decreasing the fractional secretory rates of albumin (P < 0.01 vs. water and 300 mL wine) and fibrinogen (P < 0.04 vs. water and 300 mL of wine) below the postabsorptive values. These results demonstrate that a moderate dose of alcohol (28 g, ~2 drinks) slightly affects postprandial hepatic protein metabolism by blunting the meal-induced increase in albumin synthesis, whereas it does not interfere with fibrinogen synthesis as do higher doses.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalJournal of Nutrition
Volume128
Issue number2
StatePublished - Feb 1998
Externally publishedYes

Fingerprint

Secretory Rate
liver protein
Wine
protein metabolism
fibrinogen
Ethanol
Fibrinogen
ethanol
albumins
wines
Albumins
Water
Liver
dosage
Meals
Proteins
alcohols
water
Alcohols
table wines

Keywords

  • Albumin
  • Fibrinogen
  • Humans
  • Leucine metabolism
  • Protein synthesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Volpi, E., Lucidi, P., Cruciani, G., Monacchia, F., Santoni, S., Reboldi, G., ... De Feo, P. (1998). Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans. Journal of Nutrition, 128(2), 198-203.

Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans. / Volpi, Elena; Lucidi, Paola; Cruciani, Guido; Monacchia, Francesca; Santoni, Stefania; Reboldi, Gianpaolo; Brunetti, Paolo; Bolli, Geremia B.; De Feo, Pierpaolo.

In: Journal of Nutrition, Vol. 128, No. 2, 02.1998, p. 198-203.

Research output: Contribution to journalArticle

Volpi, E, Lucidi, P, Cruciani, G, Monacchia, F, Santoni, S, Reboldi, G, Brunetti, P, Bolli, GB & De Feo, P 1998, 'Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans', Journal of Nutrition, vol. 128, no. 2, pp. 198-203.
Volpi E, Lucidi P, Cruciani G, Monacchia F, Santoni S, Reboldi G et al. Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans. Journal of Nutrition. 1998 Feb;128(2):198-203.
Volpi, Elena ; Lucidi, Paola ; Cruciani, Guido ; Monacchia, Francesca ; Santoni, Stefania ; Reboldi, Gianpaolo ; Brunetti, Paolo ; Bolli, Geremia B. ; De Feo, Pierpaolo. / Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans. In: Journal of Nutrition. 1998 ; Vol. 128, No. 2. pp. 198-203.
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