Modes of hantavirus transmission in a population of Clethrionomys rufocanus bedfordiae inferred from mitochondrial and microsatellite DNA analyses

M. A. Iwasa, H. Kariwa, B. Z. Cui, K. Lokugamage, N. Lokugamage, T. Hagiya, T. Mizutani, I. Takashima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

To elucidate the mode of transmission of Puumala-related hantavirus in a population of gray red-backed voles, Clethrionomys rufocanus bedfordiae, in Hokkaido, Japan, we analyzed the kin structure and dispersal patterns of individual voles using microsatellite and mitochondrial DNA markers. Siblings or dam/offsprings was identified within the population based on the relatedness calculation with the microsatellite data. The pairwise relatedness values obtained could reveal kinship among all vole individuals within the population. Based on the assessment of kinship, we did not find a positive relationship between hantavirus transmission and close kinship. Males infected with the hantavirus carried a relatively uncommon mitochondrial haplotype. However, these infected males shared low relatedness values and were not considered closely related, i.e., they were not siblings or parent/offspring. These observations imply that hantavirus transmission in the vole population may not be related to close kinship but by random horizontal infection.

Original languageEnglish (US)
Pages (from-to)929-941
Number of pages13
JournalArchives of Virology
Volume149
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

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Hantavirus
Arvicolinae
Mitochondrial DNA
Microsatellite Repeats
Population
Genetic Markers
Haplotypes
Japan
Infection

ASJC Scopus subject areas

  • Genetics
  • Applied Microbiology and Biotechnology

Cite this

Modes of hantavirus transmission in a population of Clethrionomys rufocanus bedfordiae inferred from mitochondrial and microsatellite DNA analyses. / Iwasa, M. A.; Kariwa, H.; Cui, B. Z.; Lokugamage, K.; Lokugamage, N.; Hagiya, T.; Mizutani, T.; Takashima, I.

In: Archives of Virology, Vol. 149, No. 5, 05.2004, p. 929-941.

Research output: Contribution to journalArticle

Iwasa, MA, Kariwa, H, Cui, BZ, Lokugamage, K, Lokugamage, N, Hagiya, T, Mizutani, T & Takashima, I 2004, 'Modes of hantavirus transmission in a population of Clethrionomys rufocanus bedfordiae inferred from mitochondrial and microsatellite DNA analyses', Archives of Virology, vol. 149, no. 5, pp. 929-941. https://doi.org/10.1007/s00705-003-0255-x
Iwasa, M. A. ; Kariwa, H. ; Cui, B. Z. ; Lokugamage, K. ; Lokugamage, N. ; Hagiya, T. ; Mizutani, T. ; Takashima, I. / Modes of hantavirus transmission in a population of Clethrionomys rufocanus bedfordiae inferred from mitochondrial and microsatellite DNA analyses. In: Archives of Virology. 2004 ; Vol. 149, No. 5. pp. 929-941.
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