TY - JOUR
T1 - Modes of hantavirus transmission in a population of Clethrionomys rufocanus bedfordiae inferred from mitochondrial and microsatellite DNA analyses
AU - Iwasa, M. A.
AU - Kariwa, H.
AU - Cui, B. Z.
AU - Lokugamage, K.
AU - Lokugamage, N.
AU - Hagiya, T.
AU - Mizutani, T.
AU - Takashima, I.
PY - 2004/5
Y1 - 2004/5
N2 - To elucidate the mode of transmission of Puumala-related hantavirus in a population of gray red-backed voles, Clethrionomys rufocanus bedfordiae, in Hokkaido, Japan, we analyzed the kin structure and dispersal patterns of individual voles using microsatellite and mitochondrial DNA markers. Siblings or dam/offsprings was identified within the population based on the relatedness calculation with the microsatellite data. The pairwise relatedness values obtained could reveal kinship among all vole individuals within the population. Based on the assessment of kinship, we did not find a positive relationship between hantavirus transmission and close kinship. Males infected with the hantavirus carried a relatively uncommon mitochondrial haplotype. However, these infected males shared low relatedness values and were not considered closely related, i.e., they were not siblings or parent/offspring. These observations imply that hantavirus transmission in the vole population may not be related to close kinship but by random horizontal infection.
AB - To elucidate the mode of transmission of Puumala-related hantavirus in a population of gray red-backed voles, Clethrionomys rufocanus bedfordiae, in Hokkaido, Japan, we analyzed the kin structure and dispersal patterns of individual voles using microsatellite and mitochondrial DNA markers. Siblings or dam/offsprings was identified within the population based on the relatedness calculation with the microsatellite data. The pairwise relatedness values obtained could reveal kinship among all vole individuals within the population. Based on the assessment of kinship, we did not find a positive relationship between hantavirus transmission and close kinship. Males infected with the hantavirus carried a relatively uncommon mitochondrial haplotype. However, these infected males shared low relatedness values and were not considered closely related, i.e., they were not siblings or parent/offspring. These observations imply that hantavirus transmission in the vole population may not be related to close kinship but by random horizontal infection.
UR - http://www.scopus.com/inward/record.url?scp=2442490809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2442490809&partnerID=8YFLogxK
U2 - 10.1007/s00705-003-0255-x
DO - 10.1007/s00705-003-0255-x
M3 - Article
C2 - 15098108
AN - SCOPUS:2442490809
SN - 0304-8608
VL - 149
SP - 929
EP - 941
JO - Archives of virology
JF - Archives of virology
IS - 5
ER -