Modification of the radiation response of mouse lung by actinomycin D: Dependence on interval between radiation and drug treatments

Martin Colman, Eileen Zabilansky, J. Leslie Redpath

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Actinomycin D (0.6 mg/kg, i.p.) enhances the radiation response of mouse lung. The degree of enhancement varies inversely with the interval between radiation and drug treatments. The kinetics of the loss of interaction of the drug with radiation damage is similar to that observed for 'slow repair' of radiation injury to the lung.

Original languageEnglish (US)
Pages (from-to)511-512
Number of pages2
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume8
Issue number3-4
DOIs
StatePublished - 1982
Externally publishedYes

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Keywords

  • Actinomycin D
  • Lung
  • Radiation injury
  • Type 2 pneumocytes

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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