Modulation of brain NMDA receptors

common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

R. Sircar, H. Samaan, R. Nichtenhauser, L. D. Snell, K. M. Johnson, J. Rivier, W. Vale, R. S. Zukin, S. R. Zukin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalNIDA research monograph
Volume75
StatePublished - 1986
Externally publishedYes

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Phencyclidine Receptors
sigma Receptors
N-Methyl-D-Aspartate Receptors
N-Methylaspartate
Ligands
Brain
Neurotransmitter Agents

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Sircar, R., Samaan, H., Nichtenhauser, R., Snell, L. D., Johnson, K. M., Rivier, J., ... Zukin, S. R. (1986). Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands. NIDA research monograph, 75, 157-160.

Modulation of brain NMDA receptors : common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands. / Sircar, R.; Samaan, H.; Nichtenhauser, R.; Snell, L. D.; Johnson, K. M.; Rivier, J.; Vale, W.; Zukin, R. S.; Zukin, S. R.

In: NIDA research monograph, Vol. 75, 1986, p. 157-160.

Research output: Contribution to journalArticle

Sircar, R, Samaan, H, Nichtenhauser, R, Snell, LD, Johnson, KM, Rivier, J, Vale, W, Zukin, RS & Zukin, SR 1986, 'Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.', NIDA research monograph, vol. 75, pp. 157-160.
Sircar, R. ; Samaan, H. ; Nichtenhauser, R. ; Snell, L. D. ; Johnson, K. M. ; Rivier, J. ; Vale, W. ; Zukin, R. S. ; Zukin, S. R. / Modulation of brain NMDA receptors : common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands. In: NIDA research monograph. 1986 ; Vol. 75. pp. 157-160.
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