Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

R. Sircar; H. Samaan; R. Nichtenhauser; L. D. Snell; K. M. Johnson; J. Rivier; W. Vale; R. S. Zukin; S. R. Zukin

Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

R. Sircar
, H. Samaan
, R. Nichtenhauser
, L. D. Snell
, K. M. Johnson
, J. Rivier
, W. Vale
, R. S. Zukin
, S. R. Zukin

Research output: Contribution to journal › Article › peer-review

Abstract

Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.

Original language	English (US)
Pages (from-to)	157-160
Number of pages	4
Journal	NIDA research monograph
Volume	75
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)

Cite this

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title = "Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.",

abstract = "Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.",

author = "R. Sircar and H. Samaan and R. Nichtenhauser and Snell, \{L. D.\} and Johnson, \{K. M.\} and J. Rivier and W. Vale and Zukin, \{R. S.\} and Zukin, \{S. R.\}",

year = "1986",

language = "English (US)",

volume = "75",

pages = "157--160",

journal = "NIDA research monograph",

issn = "1046-9516",

publisher = "National Institute on Drug Abuse",

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T1 - Modulation of brain NMDA receptors

T2 - common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

AU - Sircar, R.

AU - Samaan, H.

AU - Nichtenhauser, R.

AU - Snell, L. D.

AU - Johnson, K. M.

AU - Rivier, J.

AU - Vale, W.

AU - Zukin, R. S.

AU - Zukin, S. R.

PY - 1986

Y1 - 1986

N2 - Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.

AB - Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.

UR - https://www.scopus.com/pages/publications/0022822436

UR - https://www.scopus.com/pages/publications/0022822436#tab=citedBy

M3 - Article

C2 - 2828962

AN - SCOPUS:0022822436

SN - 1046-9516

VL - 75

SP - 157

EP - 160

JO - NIDA research monograph

JF - NIDA research monograph

ER -

Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

Abstract

ASJC Scopus subject areas

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