Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.
|Original language||English (US)|
|Number of pages||4|
|Journal||NIDA research monograph|
|State||Published - 1986|
ASJC Scopus subject areas
- Medicine (miscellaneous)