Modulation of Candida albicans attachment to human epithelial cells by bacteria and carbohydrates

A. Centeno, C. P. Davis, M. S. Cohen, M. M. Warren

    Research output: Contribution to journalArticle

    51 Scopus citations

    Abstract

    The effects of carbohydrates (mannose and dextrose), Escherichia coli 07KL, and Klebsiella pneumoniae on Candida albicans attachment to epithelial cells was studied. Dextrose had no effect on yeast attachment to epithelial cells. Conversely, mannose significantly decreased both yeast and piliated bacterial attachment (E. coli 07KL, heavily piliated K. pneumoniae), whereas having no effect on nonpiliated K. pneumoniae attachment to epithelial cells. The number of yeasts attaching to epithelial cells was enhanced by preincubation of epithelial cells with piliated strains of bacteria, whereas preincubation with nonpiliated strains of bacteria had no effect on yeast attachment. Scanning electron microscopy showed that piliated bacteria and yeasts were juxtaposed on the epithelial cell surface. These data suggest that certain piliated strains of bacteria can enhance C. albicans attachment to epithelial cells and that type 1 pili of bacteria can be a factor in the enhanced attachment of C. albicans to epithelial cells.

    Original languageEnglish (US)
    Pages (from-to)1354-1360
    Number of pages7
    JournalInfection and immunity
    Volume39
    Issue number3
    DOIs
    StatePublished - 1983

    ASJC Scopus subject areas

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases

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