Modulation of Candida albicans attachment to human epithelial cells by bacteria and carbohydrates

A. Centeno, C. P. Davis, M. S. Cohen, M. M. Warren

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The effects of carbohydrates (mannose and dextrose), Escherichia coli 07KL, and Klebsiella pneumoniae on Candida albicans attachment to epithelial cells was studied. Dextrose had no effect on yeast attachment to epithelial cells. Conversely, mannose significantly decreased both yeast and piliated bacterial attachment (E. coli 07KL, heavily piliated K. pneumoniae), whereas having no effect on nonpiliated K. pneumoniae attachment to epithelial cells. The number of yeasts attaching to epithelial cells was enhanced by preincubation of epithelial cells with piliated strains of bacteria, whereas preincubation with nonpiliated strains of bacteria had no effect on yeast attachment. Scanning electron microscopy showed that piliated bacteria and yeasts were juxtaposed on the epithelial cell surface. These data suggest that certain piliated strains of bacteria can enhance C. albicans attachment to epithelial cells and that type 1 pili of bacteria can be a factor in the enhanced attachment of C. albicans to epithelial cells.

Original languageEnglish (US)
Pages (from-to)1354-1360
Number of pages7
JournalInfection and Immunity
Volume39
Issue number3
StatePublished - 1983

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Candida albicans
Epithelial Cells
Carbohydrates
Bacteria
Yeasts
Klebsiella pneumoniae
Mannose
Escherichia coli
Glucose
Electron Scanning Microscopy

ASJC Scopus subject areas

  • Immunology

Cite this

Centeno, A., Davis, C. P., Cohen, M. S., & Warren, M. M. (1983). Modulation of Candida albicans attachment to human epithelial cells by bacteria and carbohydrates. Infection and Immunity, 39(3), 1354-1360.

Modulation of Candida albicans attachment to human epithelial cells by bacteria and carbohydrates. / Centeno, A.; Davis, C. P.; Cohen, M. S.; Warren, M. M.

In: Infection and Immunity, Vol. 39, No. 3, 1983, p. 1354-1360.

Research output: Contribution to journalArticle

Centeno, A, Davis, CP, Cohen, MS & Warren, MM 1983, 'Modulation of Candida albicans attachment to human epithelial cells by bacteria and carbohydrates', Infection and Immunity, vol. 39, no. 3, pp. 1354-1360.
Centeno, A. ; Davis, C. P. ; Cohen, M. S. ; Warren, M. M. / Modulation of Candida albicans attachment to human epithelial cells by bacteria and carbohydrates. In: Infection and Immunity. 1983 ; Vol. 39, No. 3. pp. 1354-1360.
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