TY - JOUR
T1 - Modulation of gene expression regulated by the transcription factor nf-κb/rela
AU - Li, Xueling
AU - Zhao, Yingxin
AU - Tian, Bing
AU - Jamaluddin, Mohammad
AU - Mitra, Abhishek
AU - Yang, Jun
AU - Rowicka, Maga
AU - Brasier, Allan R.
AU - Kudlicki, Andrzej
PY - 2014/4/25
Y1 - 2014/4/25
N2 - Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.
AB - Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.
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U2 - 10.1074/jbc.M113.539965
DO - 10.1074/jbc.M113.539965
M3 - Article
C2 - 24523406
AN - SCOPUS:84899464281
VL - 289
SP - 11927
EP - 11944
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 17
ER -