Modulation of gene expression regulated by the transcription factor nf-κb/rela

Xueling Li, Yingxin Zhao, Bing Tian, Mohammad Jamaluddin, Abhishek Mitra, Jun Yang, Malgorzata Rowicka-Kudlicka, Allan R. Brasier, Andrzej Kudlicki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.

Original languageEnglish
Pages (from-to)11927-11944
Number of pages18
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - Apr 25 2014

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Transcription Factor RelA
DNA-Binding Proteins
Gene expression
Modulators
Transcription Factors
Modulation
Gene Expression
Protein Binding
Proteins
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Modulation of gene expression regulated by the transcription factor nf-κb/rela. / Li, Xueling; Zhao, Yingxin; Tian, Bing; Jamaluddin, Mohammad; Mitra, Abhishek; Yang, Jun; Rowicka-Kudlicka, Malgorzata; Brasier, Allan R.; Kudlicki, Andrzej.

In: Journal of Biological Chemistry, Vol. 289, No. 17, 25.04.2014, p. 11927-11944.

Research output: Contribution to journalArticle

Li, Xueling ; Zhao, Yingxin ; Tian, Bing ; Jamaluddin, Mohammad ; Mitra, Abhishek ; Yang, Jun ; Rowicka-Kudlicka, Malgorzata ; Brasier, Allan R. ; Kudlicki, Andrzej. / Modulation of gene expression regulated by the transcription factor nf-κb/rela. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 17. pp. 11927-11944.
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