Modulation of gene expression regulated by the transcription factor nf-κb/rela

Xueling Li; Yingxin Zhao; Bing Tian; Mohammad Jamaluddin; Abhishek Mitra; Jun Yang; Maga Rowicka; Allan R. Brasier; Andrzej Kudlicki

doi:10.1074/jbc.M113.539965

Modulation of gene expression regulated by the transcription factor nf-κb/rela

Xueling Li, Yingxin Zhao, Bing Tian, Mohammad Jamaluddin, Abhishek Mitra, Jun Yang, Maga Rowicka, Allan R. Brasier, Andrzej Kudlicki

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.

Original language	English (US)
Pages (from-to)	11927-11944
Number of pages	18
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M113.539965
State	Published - Apr 25 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Modulation of gene expression regulated by the transcription factor nf-κb/rela. / Li, Xueling; Zhao, Yingxin ; Tian, Bing; Jamaluddin, Mohammad; Mitra, Abhishek; Yang, Jun ; Rowicka, Maga; Brasier, Allan R.; Kudlicki, Andrzej.

In: Journal of Biological Chemistry, Vol. 289, No. 17, 25.04.2014, p. 11927-11944.

Research output: Contribution to journal › Article › peer-review

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AU - Yang, Jun

AU - Rowicka, Maga

AU - Brasier, Allan R.

AU - Kudlicki, Andrzej

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