Abstract
Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 11927-11944 |
| Number of pages | 18 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 17 |
| DOIs | |
| State | Published - Apr 25 2014 |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Modulation of gene expression regulated by the transcription factor nf-κb/rela. / Li, Xueling; Zhao, Yingxin; Tian, Bing; Jamaluddin, Mohammad; Mitra, Abhishek; Yang, Jun; Rowicka-Kudlicka, Malgorzata; Brasier, Allan R.; Kudlicki, Andrzej.
In: Journal of Biological Chemistry, Vol. 289, No. 17, 25.04.2014, p. 11927-11944.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of gene expression regulated by the transcription factor nf-κb/rela
AU - Li, Xueling
AU - Zhao, Yingxin
AU - Tian, Bing
AU - Jamaluddin, Mohammad
AU - Mitra, Abhishek
AU - Yang, Jun
AU - Rowicka-Kudlicka, Malgorzata
AU - Brasier, Allan R.
AU - Kudlicki, Andrzej
PY - 2014/4/25
Y1 - 2014/4/25
N2 - Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.
AB - Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.
UR - http://www.scopus.com/inward/record.url?scp=84899464281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899464281&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.539965
DO - 10.1074/jbc.M113.539965
M3 - Article
VL - 289
SP - 11927
EP - 11944
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 17
ER -