Modulation of gene expression regulated by the transcription factor nf-κb/rela

Xueling Li, Yingxin Zhao, Bing Tian, Mohammad Jamaluddin, Abhishek Mitra, Jun Yang, Maga Rowicka, Allan R. Brasier, Andrzej Kudlicki

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.

Original languageEnglish (US)
Pages (from-to)11927-11944
Number of pages18
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - Apr 25 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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