Abstract
Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11927-11944 |
| Number of pages | 18 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 17 |
| DOIs | |
| State | Published - Apr 25 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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Li, X., Zhao, Y., Tian, B., Jamaluddin, M., Mitra, A., Yang, J., Rowicka, M., Brasier, A. R., & Kudlicki, A. (2014). Modulation of gene expression regulated by the transcription factor nf-κb/rela. Journal of Biological Chemistry, 289(17), 11927-11944. https://doi.org/10.1074/jbc.M113.539965