Modulation of gene expression regulated by the transcription factor nf-κb/rela

Xueling Li; Yingxin Zhao; Bing Tian; Mohammad Jamaluddin; Abhishek Mitra; Jun Yang; Maga Rowicka; Allan R. Brasier; Andrzej Kudlicki

doi:10.1074/jbc.M113.539965

Modulation of gene expression regulated by the transcription factor nf-κb/rela

Xueling Li
, Yingxin Zhao
, Bing Tian
, Mohammad Jamaluddin
, Abhishek Mitra
, Jun Yang
, Maga Rowicka
, Allan R. Brasier
, Andrzej Kudlicki

Internal Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.

Original language	English (US)
Pages (from-to)	11927-11944
Number of pages	18
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M113.539965
State	Published - Apr 25 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.539965

Cite this

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title = "Modulation of gene expression regulated by the transcription factor nf-κb/rela",

abstract = "Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.",

author = "Xueling Li and Yingxin Zhao and Bing Tian and Mohammad Jamaluddin and Abhishek Mitra and Jun Yang and Maga Rowicka and Brasier, \{Allan R.\} and Andrzej Kudlicki",

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AU - Li, Xueling

AU - Zhao, Yingxin

AU - Tian, Bing

AU - Jamaluddin, Mohammad

AU - Mitra, Abhishek

AU - Yang, Jun

AU - Rowicka, Maga

AU - Brasier, Allan R.

AU - Kudlicki, Andrzej

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.

AB - Background: Interacting proteins modulate the activity of NF-κB/RelA transcription factor and expression of its targets. Results: By analyzing gene expression, protein binding, and DNA binding, we inferred and characterized 8349 such modulations. Conclusion: Different modulator groups affect separate pathways. Significance: We provide new insight into the activity of NF-κB/RelA. Our inference model can be applied to other processes and pathways.

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UR - https://www.scopus.com/pages/publications/84899464281#tab=citedBy

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EP - 11944

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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ER -

Modulation of gene expression regulated by the transcription factor nf-κb/rela

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