Although it is clear that respiratory virus infections frequently provoke attacks of asthma, the mechanism of the provocation is unknown. The accumulation of basophils in the sputum and the presence of basophil chemotactic factors in the serum of allergic patients suggests that the basophil may play a causative role in asthmatic attacks. We have investigated the effect of viruses on the in vitro migration of human basophils. When peripheral blood leukocytes from normal subjects were preincubated for 24 hr with uv-inactivated Sendai virus, the chemotactic response of basophils was augmented. This effect was also seen with the cell-free supernatant of mononuclear cells cultured with virus. Our results suggest that the soluble product mediating the enhancement is interferon. While the soluble factor enhanced basophil migration toward two chemoattractants (C5 peptide and a synthetic formyl-tripeptide), it has no effect on the migration of monocytes.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine