Modulation of membrane dynamics and cell motility by membrane tension

Michael Sheetz, Jianwu Dai

Research output: Contribution to journalComment/debate

175 Citations (Scopus)

Abstract

The plasma membrane of most cells is drawn tightly over the cytoskeleton of the cell, resulting in a significant tension being developed in the membrane. The tension in the membrane can be calculated from the force required to separate it from the cytoskeleton; and the force itself can be measured rapidly by using laser tweezers. Recent observations indicate that decreasing membrane tension stimulates endocytosis and increasing tension stimulates secretion. Thus, membrane tension provides a simple physical mechanism to control the area of the plasma membrane. Here, we speculate that tension is a global parameter that the cell uses to control physically plasma membrane dynamics, cell shape and cell motility.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalTrends in Cell Biology
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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Cell Movement
Cell Membrane
Membranes
Cytoskeleton
Optical Tweezers
Cell Shape
Endocytosis

ASJC Scopus subject areas

  • Cell Biology

Cite this

Modulation of membrane dynamics and cell motility by membrane tension. / Sheetz, Michael; Dai, Jianwu.

In: Trends in Cell Biology, Vol. 6, No. 3, 01.01.1996, p. 85-89.

Research output: Contribution to journalComment/debate

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