Modulation of the hypermetabolic response after burn injury

Ashley Guillory; Craig Porter; Oscar E. Suman; Ramon L. Zapata-Sirvent; Celeste C. Finnerty; David Herndon

doi:10.1016/B978-0-323-47661-4.00029-0

Modulation of the hypermetabolic response after burn injury

Ashley Guillory, Craig Porter, Oscar E. Suman, Ramon L. Zapata-Sirvent, Celeste C. Finnerty, David Herndon

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

12 Scopus citations

Abstract

The hypermetabolic response to severe burn injury can profoundly delay recovery and rehabilitation after the injury. Increased cardiac work, elevated resting energy expenditure, and loss of lean body mass with subsequent decreased muscle strength result from post-burn hypermetabolism. Additionally, elements of the hypermetabolic response remain elevated above normal for up to 3 years. This chapter reviews the metabolic alterations that occur after severe burn injury as well as various pharmacological therapies that are being used and/or investigated for use to attenuate the hypermetabolic response.

Original language	English (US)
Title of host publication	Total Burn Care
Subtitle of host publication	Fifth Edition
Publisher	Elsevier Inc.
Pages	301-306.e3
ISBN (Electronic)	9780323497428
ISBN (Print)	9780323476614
DOIs	https://doi.org/10.1016/B978-0-323-47661-4.00029-0
State	Published - 2018

Keywords

Growth hormone
Hypermetabolism
Insulin
Metformin
Oxandrolone
Propranolol

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-47661-4.00029-0

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title = "Modulation of the hypermetabolic response after burn injury",

abstract = "The hypermetabolic response to severe burn injury can profoundly delay recovery and rehabilitation after the injury. Increased cardiac work, elevated resting energy expenditure, and loss of lean body mass with subsequent decreased muscle strength result from post-burn hypermetabolism. Additionally, elements of the hypermetabolic response remain elevated above normal for up to 3 years. This chapter reviews the metabolic alterations that occur after severe burn injury as well as various pharmacological therapies that are being used and/or investigated for use to attenuate the hypermetabolic response.",

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AU - Herndon, David

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AB - The hypermetabolic response to severe burn injury can profoundly delay recovery and rehabilitation after the injury. Increased cardiac work, elevated resting energy expenditure, and loss of lean body mass with subsequent decreased muscle strength result from post-burn hypermetabolism. Additionally, elements of the hypermetabolic response remain elevated above normal for up to 3 years. This chapter reviews the metabolic alterations that occur after severe burn injury as well as various pharmacological therapies that are being used and/or investigated for use to attenuate the hypermetabolic response.

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KW - Hypermetabolism

KW - Insulin

KW - Metformin

KW - Oxandrolone

KW - Propranolol

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ER -

Modulation of the hypermetabolic response after burn injury

Abstract

Keywords

ASJC Scopus subject areas

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