Molecular analysis of rubella virus epidemiology across three continents, North America, Europe, and Asia, 1961-1997

Teryl K. Frey, Emily S. Abernathy, Trent J. Bosnia, William G. Starkey, Karen M. Corbett, Jennifer M. Best, Shigetaka Katow, Scott Weaver

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

E1 gene nucleotide sequences of 63 rubella virus isolates from North America, Europe, and Asia isolated between 1961 and 1997 were compared phylogenetically. Two genotypes were evident: Genotype I contained 60 viruses from North America, Europe, and Japan, and genotype II contained 3 viruses from China and India. The genotype I isolates prior to 1970 grouped into a single diffuse clade, indicating intercontinental circulation, while most post-1975 viruses segregated into geographic clades from each continent, indicating evolution in response to vaccination programs. The E1 amino acid sequences differed by no more than 3%; thus, no major antigenic variation was apparent. Among 4 viruses from congenital rubella syndrome that occurred following reinfection, only one amino acid substitution occurred in several important epitopes, indicating that antigenic drift is not important in this phenomenon. However, 2 viruses isolated from chronic arthritis exhibited changes in these epitopes. Isolates of the RA 27/3 vaccine strain were readily identifiable by nucleotide sequence.

Original languageEnglish (US)
Pages (from-to)642-650
Number of pages9
JournalJournal of Infectious Diseases
Volume178
Issue number3
StatePublished - 1998
Externally publishedYes

Fingerprint

Northern Asia
Rubella virus
North America
Epidemiology
Viruses
Genotype
Epitopes
Congenital Rubella Syndrome
Antigenic Variation
Amino Acid Substitution
Arthritis
India
Amino Acid Sequence
China
Japan
Vaccination
Vaccines
Genes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Frey, T. K., Abernathy, E. S., Bosnia, T. J., Starkey, W. G., Corbett, K. M., Best, J. M., ... Weaver, S. (1998). Molecular analysis of rubella virus epidemiology across three continents, North America, Europe, and Asia, 1961-1997. Journal of Infectious Diseases, 178(3), 642-650.

Molecular analysis of rubella virus epidemiology across three continents, North America, Europe, and Asia, 1961-1997. / Frey, Teryl K.; Abernathy, Emily S.; Bosnia, Trent J.; Starkey, William G.; Corbett, Karen M.; Best, Jennifer M.; Katow, Shigetaka; Weaver, Scott.

In: Journal of Infectious Diseases, Vol. 178, No. 3, 1998, p. 642-650.

Research output: Contribution to journalArticle

Frey, TK, Abernathy, ES, Bosnia, TJ, Starkey, WG, Corbett, KM, Best, JM, Katow, S & Weaver, S 1998, 'Molecular analysis of rubella virus epidemiology across three continents, North America, Europe, and Asia, 1961-1997', Journal of Infectious Diseases, vol. 178, no. 3, pp. 642-650.
Frey, Teryl K. ; Abernathy, Emily S. ; Bosnia, Trent J. ; Starkey, William G. ; Corbett, Karen M. ; Best, Jennifer M. ; Katow, Shigetaka ; Weaver, Scott. / Molecular analysis of rubella virus epidemiology across three continents, North America, Europe, and Asia, 1961-1997. In: Journal of Infectious Diseases. 1998 ; Vol. 178, No. 3. pp. 642-650.
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abstract = "E1 gene nucleotide sequences of 63 rubella virus isolates from North America, Europe, and Asia isolated between 1961 and 1997 were compared phylogenetically. Two genotypes were evident: Genotype I contained 60 viruses from North America, Europe, and Japan, and genotype II contained 3 viruses from China and India. The genotype I isolates prior to 1970 grouped into a single diffuse clade, indicating intercontinental circulation, while most post-1975 viruses segregated into geographic clades from each continent, indicating evolution in response to vaccination programs. The E1 amino acid sequences differed by no more than 3{\%}; thus, no major antigenic variation was apparent. Among 4 viruses from congenital rubella syndrome that occurred following reinfection, only one amino acid substitution occurred in several important epitopes, indicating that antigenic drift is not important in this phenomenon. However, 2 viruses isolated from chronic arthritis exhibited changes in these epitopes. Isolates of the RA 27/3 vaccine strain were readily identifiable by nucleotide sequence.",
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