Molecular and biomarker analyses of salivary duct carcinomas

comparison with mammary duct carcinoma.

M. P. Hoang, David Callender, J. J. Sola Gallego, Z. Huang, N. Sneige, M. A. Luna, J. G. Batsakis, A. K. El-Naggar

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Salivary duct carcinoma (SDC) is a rare high-grade aggressive neoplasm that manifests close histologic features with invasive ductal carcinoma of the breast (IDC). In contrast to SDC, extensive molecular studies have been performed on IDC and led to the identification of certain biological markers. To investigate the underlying molecular and biologic characteristics of SDC, we performed molecular analyses using microsatellite markers on chromosomal arms 6q, 16q, 17p, and 17q, DNA flow cytometry and immunohistochemical staining for androgen receptor (AR) and p53 expression on 28 examples of these tumors in comparison to 24 IDC cases. Our results show that generally similar allelic alterations, elevated p53 and androgen receptor expressions, and high frequency of DNA aneuploidy are manifested in both SDCs and IDCs. Differences at certain markers on 6q, 17p and 17q chromosomal loci, however, were observed between the two entities. Certain loci on 6q were more frequently altered in SDC than IDC which loci on chromosomes 17p and q arms were more seen in IDCs than SDCs. The majority of SDCs had high AR expression while most of IDCs were AR negative. Our study indicates that: i) SDC may share some genetic alterations with IDC, ii) high AR expression in SDC may play a role in tumor progression, and iii) p53 overexpression and DNA aneuploidy in both entities reflect their aggressive behavior.

Original languageEnglish (US)
Pages (from-to)865-871
Number of pages7
JournalInternational Journal of Oncology
Volume19
Issue number4
StatePublished - Oct 2001
Externally publishedYes

Fingerprint

Salivary Ducts
Carcinoma, Ductal, Breast
Androgen Receptors
Biomarkers
Breast Neoplasms
Carcinoma
Aneuploidy
DNA
Arm
Neoplasms
Microsatellite Repeats
Flow Cytometry
Chromosomes
Staining and Labeling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hoang, M. P., Callender, D., Sola Gallego, J. J., Huang, Z., Sneige, N., Luna, M. A., ... El-Naggar, A. K. (2001). Molecular and biomarker analyses of salivary duct carcinomas: comparison with mammary duct carcinoma. International Journal of Oncology, 19(4), 865-871.

Molecular and biomarker analyses of salivary duct carcinomas : comparison with mammary duct carcinoma. / Hoang, M. P.; Callender, David; Sola Gallego, J. J.; Huang, Z.; Sneige, N.; Luna, M. A.; Batsakis, J. G.; El-Naggar, A. K.

In: International Journal of Oncology, Vol. 19, No. 4, 10.2001, p. 865-871.

Research output: Contribution to journalArticle

Hoang, MP, Callender, D, Sola Gallego, JJ, Huang, Z, Sneige, N, Luna, MA, Batsakis, JG & El-Naggar, AK 2001, 'Molecular and biomarker analyses of salivary duct carcinomas: comparison with mammary duct carcinoma.', International Journal of Oncology, vol. 19, no. 4, pp. 865-871.
Hoang MP, Callender D, Sola Gallego JJ, Huang Z, Sneige N, Luna MA et al. Molecular and biomarker analyses of salivary duct carcinomas: comparison with mammary duct carcinoma. International Journal of Oncology. 2001 Oct;19(4):865-871.
Hoang, M. P. ; Callender, David ; Sola Gallego, J. J. ; Huang, Z. ; Sneige, N. ; Luna, M. A. ; Batsakis, J. G. ; El-Naggar, A. K. / Molecular and biomarker analyses of salivary duct carcinomas : comparison with mammary duct carcinoma. In: International Journal of Oncology. 2001 ; Vol. 19, No. 4. pp. 865-871.
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