Molecular architecture of bacteriophage T4

V. V. Mesyanzhinov, P. G. Leiman, V. A. Kostyuchenko, L. P. Kurochkina, K. A. Miroshnikov, N. N. Sykilinda, M. M. Shneider

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

In studying bacteriophage T4 - one of the basic models of molecular biology for several decades - there has come a Renaissance, and this virus is now actively used as object of structural biology. The structures of six proteins of the phage particle have recently been determined at atomic resolution by X-ray crystallography. Three-dimensional reconstruction of the infection device - one of the most complex multiprotein components-has been developed on the basis of cryo-electron microscopy images. The further study of bacteriophage T4 structure will allow a better understanding of the regulation of protein folding, assembly of biological structures, and also mechanisms of functioning of the complex biological molecular machines.

Original languageEnglish (US)
Pages (from-to)1190-1202
Number of pages13
JournalBiochemistry (Moscow)
Volume69
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

Keywords

  • 3D reconstruction
  • Bacteriophage T4
  • Baseplate
  • Cryo-electron microscopy
  • Infection mechanisms
  • Protein structure
  • Tail sheath
  • Virus structure
  • X-ray analysis

ASJC Scopus subject areas

  • Biochemistry

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