Molecular architecture of bacteriophage T4

V. V. Mesyanzhinov, Petr Leiman, V. A. Kostyuchenko, L. P. Kurochkina, K. A. Miroshnikov, N. N. Sykilinda, M. M. Shneider

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In studying bacteriophage T4 - one of the basic models of molecular biology for several decades - there has come a Renaissance, and this virus is now actively used as object of structural biology. The structures of six proteins of the phage particle have recently been determined at atomic resolution by X-ray crystallography. Three-dimensional reconstruction of the infection device - one of the most complex multiprotein components-has been developed on the basis of cryo-electron microscopy images. The further study of bacteriophage T4 structure will allow a better understanding of the regulation of protein folding, assembly of biological structures, and also mechanisms of functioning of the complex biological molecular machines.

Original languageEnglish (US)
Pages (from-to)1190-1202
Number of pages13
JournalBiochemistry (Moscow)
Volume69
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Bacteriophage T4
Bacteriophages
Cryoelectron Microscopy
Multiprotein Complexes
X Ray Crystallography
Protein Folding
Protein folding
Molecular Biology
Molecular biology
X ray crystallography
Viruses
Equipment and Supplies
Electron microscopy
Infection
Proteins
Renaissance

Keywords

  • 3D reconstruction
  • Bacteriophage T4
  • Baseplate
  • Cryo-electron microscopy
  • Infection mechanisms
  • Protein structure
  • Tail sheath
  • Virus structure
  • X-ray analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Mesyanzhinov, V. V., Leiman, P., Kostyuchenko, V. A., Kurochkina, L. P., Miroshnikov, K. A., Sykilinda, N. N., & Shneider, M. M. (2004). Molecular architecture of bacteriophage T4. Biochemistry (Moscow), 69(11), 1190-1202. https://doi.org/10.1007/s10541-005-0064-9

Molecular architecture of bacteriophage T4. / Mesyanzhinov, V. V.; Leiman, Petr; Kostyuchenko, V. A.; Kurochkina, L. P.; Miroshnikov, K. A.; Sykilinda, N. N.; Shneider, M. M.

In: Biochemistry (Moscow), Vol. 69, No. 11, 11.2004, p. 1190-1202.

Research output: Contribution to journalArticle

Mesyanzhinov, VV, Leiman, P, Kostyuchenko, VA, Kurochkina, LP, Miroshnikov, KA, Sykilinda, NN & Shneider, MM 2004, 'Molecular architecture of bacteriophage T4', Biochemistry (Moscow), vol. 69, no. 11, pp. 1190-1202. https://doi.org/10.1007/s10541-005-0064-9
Mesyanzhinov VV, Leiman P, Kostyuchenko VA, Kurochkina LP, Miroshnikov KA, Sykilinda NN et al. Molecular architecture of bacteriophage T4. Biochemistry (Moscow). 2004 Nov;69(11):1190-1202. https://doi.org/10.1007/s10541-005-0064-9
Mesyanzhinov, V. V. ; Leiman, Petr ; Kostyuchenko, V. A. ; Kurochkina, L. P. ; Miroshnikov, K. A. ; Sykilinda, N. N. ; Shneider, M. M. / Molecular architecture of bacteriophage T4. In: Biochemistry (Moscow). 2004 ; Vol. 69, No. 11. pp. 1190-1202.
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