TY - JOUR
T1 - Molecular aspects of soluble guanylyl cyclase regulation
AU - Andreopoulos, Stavroula
AU - Papapetropoulos, Andreas
PY - 2000
Y1 - 2000
N2 - Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme (comprised of α and β subunits) that generates the intracellular second messenger cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). cGMP is subsequently important for the regulation of protein kinases, ion channels, and phosphodiesterases. Since recent evidence has demonstrated that heterodimerization of the α/β subunits is essential for basal and stimulated enzymatic activity, the existence of several types of isoforms for each of the two subunits, along with their varying degrees of expression in different tissues, implies that multiple regulatory mechanisms exist for sGC. Yet, progress in studying and clarifying the regulatory processes that can alter sGC expression and activity has only slowly started being elucidated. In the following paper, we elaborate on sGC structure, function, and distribution along with recently described signaling pathways that modulate sGC gene expression. Copyright (C) 2000 Elsevier Science Inc.
AB - Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme (comprised of α and β subunits) that generates the intracellular second messenger cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). cGMP is subsequently important for the regulation of protein kinases, ion channels, and phosphodiesterases. Since recent evidence has demonstrated that heterodimerization of the α/β subunits is essential for basal and stimulated enzymatic activity, the existence of several types of isoforms for each of the two subunits, along with their varying degrees of expression in different tissues, implies that multiple regulatory mechanisms exist for sGC. Yet, progress in studying and clarifying the regulatory processes that can alter sGC expression and activity has only slowly started being elucidated. In the following paper, we elaborate on sGC structure, function, and distribution along with recently described signaling pathways that modulate sGC gene expression. Copyright (C) 2000 Elsevier Science Inc.
KW - Cyclic guanosine monophosphate (cGMP)
KW - Nitric oxide (NO)
KW - Soluble guanylyl cyclase (sGC)
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U2 - 10.1016/S0306-3623(00)00062-8
DO - 10.1016/S0306-3623(00)00062-8
M3 - Review article
C2 - 11120376
AN - SCOPUS:0033646732
SN - 0306-3623
VL - 34
SP - 147
EP - 157
JO - General Pharmacology: The Vascular System
JF - General Pharmacology: The Vascular System
IS - 3
ER -