Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Keyphrases

• 2′-O-methylation 100%
• Adenosine 20%
• Dengue Virus 100%
• Efficient Expression 20%
• Evolutionary 20%
• Exoribonuclease 20%
• Flavivirus 60%
• Genome Sequencing 20%
• Global Diseases 20%
• Host Innate Immune Response 20%
• Human Infection 20%
• Innate Immunity Evasion 20%
• Methyl Transfer 20%
• Methylation Reaction 20%
• Methyltransferase Activity 20%
• MRNA Cap 40%
• Mutagenesis Studies 20%
• N-terminal Region 20%
• NS5A 100%
• Pregenomic RNA (pgRNA) 100%
• RNA Binding 20%
• RNA Genome 40%
• RNA Methyltransferase 20%
• RNA Recognition 100%
• RNA Sequencing (RNA-seq) 20%
• RNA Substrates 20%
• S-adenosylhomocysteine 20%
• Structural Modification 20%
• Ternary Complex 20%
• Tetrad 20%
• Transfer Reactions 20%
• Viral Genome 20%
• Viral Proteins 20%
• Virus RNA 40%

Biochemistry, Genetics and Molecular Biology

• Adenosine 11%
• Capping Phenomenon 22%
• Crystal Structure 11%
• Dengue Virus 100%
• Exoribonuclease 11%
• Flavivirus 33%
• Innate Immunity 22%
• Methylation 100%
• Methyltransferase 11%
• Mutagenesis Study 11%
• N-Terminus 11%
• O-Methylation 11%
• Ribose 100%
• RNA 100%
• RNA Binding 11%
• RNA Sequence 11%
• RNA Virus 22%
• S-Adenosyl-L-Homocysteine 11%
• Serotype 11%
• Ternary Complex 11%
• Viral Protein 11%

Immunology and Microbiology

• Amino Terminal Sequence 20%
• Capping Phenomenon 40%
• Crystal Structure 20%
• Dengue Virus 100%
• Flavivirus 60%
• Innate Immune System 40%
• Methylation 100%
• Mutagenesis 20%
• RNA Binding 20%
• RNA Sequence 20%
• Serotype 20%
• Vaccine Efficacy 20%
• Viral Protein 20%