Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer (Review)

Keyphrases

• Cellular Response 100%
• Cisplatin 100%
• Non-small Cell Lung Cancer (NSCLC) 100%
• Cisplatin-based Chemotherapy 100%
• DNA Damage 25%
• Molecular Mechanism 25%
• Apoptosis Induction 25%
• Apoptosis 12%
• Altered Expression 12%
• Cancer Mortality 12%
• Cancer Causes 12%
• Lung 12%
• Novel Therapeutics 12%
• Therapeutic Approaches 12%
• DNA Adducts 12%
• Possible Mechanisms 12%
• Molecular Events 12%
• Phosphoinositide 3-kinase (PI3K) 12%
• Caspase 12%
• Cytotoxicity 12%
• Effective Treatment 12%
• Regulatory Proteins 12%
• Glutathione 12%
• Solid Tumors 12%
• Response Mechanism 12%
• Apoptotic Genes 12%
• Bcl-2 Family 12%
• Systemic Chemotherapy 12%
• Cancer Morbidity 12%
• Anticancer Agents 12%
• Clinical Activity 12%
• Acquired Resistance 12%
• Biological Mechanisms 12%
• Non-small Cell Lung Cancer Cells 12%
• Combination Treatment 12%
• Resistance Development 12%
• Multiple Signaling Pathways 12%
• Intracellular Accumulation 12%
• Chemoresistance 12%
• Western World 12%
• Drug Resistance Reversal 12%
• Intrinsic Apoptosis 12%
• Oncogene Proteins 12%
• Cyclin-CDK 12%
• Metallothionine 12%
• Drug Inactivation 12%
• Cisplatin Therapy 12%
• Cisplatin-based Therapy 12%
• Interaction with DNA 12%
• Repair Mechanism 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Non Small Cell Lung Cancer 100%
• Cisplatin 100%
• Chemotherapy Regimens 100%
• Drug Resistance 16%
• Malignant Neoplasm 8%
• Glutathione 8%
• Protein P53 8%
• Antiapoptotic 8%
• Caspase 8%
• Anticarcinogen 8%
• Morbidity 8%
• Cycline 8%
• Solid Malignant Neoplasm 8%
• Regulator Protein 8%
• Oncoprotein 8%
• Cytotoxicity 8%
• Diseases 8%