Molecular basis of cisplatin resistance in human carcinomas: Model systems and patients

K. J. Scanlon, M. Kashani-Sabet, H. Miyachi, L. C. Sowers, J. Rossi

Research output: Contribution to journalReview article

117 Scopus citations

Abstract

In this review, cisplatin resistance will be summarized. We will discuss characteristics of potential mechanisms of resistance in tissues from patients with ovarian, colon and breast carcinoma. Secondly, a new molecular biology assay will be discussed which detects changes in gene expression in cisplatin-resistant cells. Finally, based on the biochemical and molecular properties of cisplatin-resistant tumors, new strategies to exploit or circumvent cisplatin resistance in human tumors wil be entertained.

Original languageEnglish (US)
Pages (from-to)1301-1312
Number of pages12
JournalAnticancer Research
Volume9
Issue number5
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Scanlon, K. J., Kashani-Sabet, M., Miyachi, H., Sowers, L. C., & Rossi, J. (1989). Molecular basis of cisplatin resistance in human carcinomas: Model systems and patients. Anticancer Research, 9(5), 1301-1312.