Molecular basis of cisplatin resistance in human carcinomas: Model systems and patients

K. J. Scanlon, M. Kashani-Sabet, H. Miyachi, Lawrence Sowers, J. Rossi

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

In this review, cisplatin resistance will be summarized. We will discuss characteristics of potential mechanisms of resistance in tissues from patients with ovarian, colon and breast carcinoma. Secondly, a new molecular biology assay will be discussed which detects changes in gene expression in cisplatin-resistant cells. Finally, based on the biochemical and molecular properties of cisplatin-resistant tumors, new strategies to exploit or circumvent cisplatin resistance in human tumors wil be entertained.

Original languageEnglish (US)
Pages (from-to)1301-1312
Number of pages12
JournalAnticancer Research
Volume9
Issue number5
StatePublished - 1989
Externally publishedYes

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Cisplatin
Carcinoma
Molecular Biology
Neoplasms
Colon
Breast Neoplasms
Gene Expression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Scanlon, K. J., Kashani-Sabet, M., Miyachi, H., Sowers, L., & Rossi, J. (1989). Molecular basis of cisplatin resistance in human carcinomas: Model systems and patients. Anticancer Research, 9(5), 1301-1312.

Molecular basis of cisplatin resistance in human carcinomas : Model systems and patients. / Scanlon, K. J.; Kashani-Sabet, M.; Miyachi, H.; Sowers, Lawrence; Rossi, J.

In: Anticancer Research, Vol. 9, No. 5, 1989, p. 1301-1312.

Research output: Contribution to journalArticle

Scanlon, KJ, Kashani-Sabet, M, Miyachi, H, Sowers, L & Rossi, J 1989, 'Molecular basis of cisplatin resistance in human carcinomas: Model systems and patients', Anticancer Research, vol. 9, no. 5, pp. 1301-1312.
Scanlon, K. J. ; Kashani-Sabet, M. ; Miyachi, H. ; Sowers, Lawrence ; Rossi, J. / Molecular basis of cisplatin resistance in human carcinomas : Model systems and patients. In: Anticancer Research. 1989 ; Vol. 9, No. 5. pp. 1301-1312.
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