TY - JOUR
T1 - Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer
AU - Poluri, Krishna Mohan
AU - Joseph, Prem Raj B.
AU - Sawant, Kirti V.
AU - Rajarathnam, Krishna
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Background: Glycosaminoglycan (GAG)-chemokine dimer interactions regulate neutrophil trafficking, but the molecular basis underlying their interactions is not well understood. Results:NMRstudies of murine CXCL1 indicate that heparin spans the dimer interface and enhances its structural integrity and stability. Conclusion: Heparin binding modulates multiple structural properties of the chemokine dimer. Significance: This study provides novel structural insights into how chemokine dimers orchestrate neutrophil recruitment.
AB - Background: Glycosaminoglycan (GAG)-chemokine dimer interactions regulate neutrophil trafficking, but the molecular basis underlying their interactions is not well understood. Results:NMRstudies of murine CXCL1 indicate that heparin spans the dimer interface and enhances its structural integrity and stability. Conclusion: Heparin binding modulates multiple structural properties of the chemokine dimer. Significance: This study provides novel structural insights into how chemokine dimers orchestrate neutrophil recruitment.
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U2 - 10.1074/jbc.M113.492579
DO - 10.1074/jbc.M113.492579
M3 - Article
C2 - 23864653
AN - SCOPUS:84883318589
SN - 0021-9258
VL - 288
SP - 25143
EP - 25153
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 35
ER -