Molecular characterization of Capim and Enseada orthobunyaviruses

William Marciel de Souza, Gustavo Olszanski Acrani, Marilia Farignoli Romeiro, Osvaldo Reis, Aline Lavado Tolardo, Sandro Patroca da Silva, Daniele Barbosa de Almeida Medeiros, Mariana Varela, Márcio Roberto Teixeira Nunes, Luiz Tadeu Moraes Figueiredo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Capim and Enseada viruses are members of the genus Orthobunyavirus isolated from mosquitoes and mammals in Brazil. Despite seroprevalence studies indicating human infections in Latin America, these viruses remain relatively unknown and unstudied. In order to better understand the genetic and evolutionary relationships among orthobunyaviruses, we sequenced the three genomic segments of Capim and Enseada orthobunyaviruses. Based on phylogenetic analysis, we demonstrated that these viruses depicted two new distinct clades, one represented by Enseada and another composed of Capim virus. In general, the genome organization and genetic traits of these viruses are similar to other orthobunyaviruses however, the open reading frame (ORF) of the putative nonstructural NSs protein of Enseada orthobunyavirus precedes the nucleocapsid ORF. Overall, our study provides details on the molecular characteristics of the prototype species of two groups within the Orthobunyavirus genus, revealing novel features into the genetic diversity and evolution of this genus.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalInfection, Genetics and Evolution
Volume40
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Keywords

  • Arbovirus
  • Bunyavirus
  • Capim orthobunyavirus
  • Enseada orthobunyavirus
  • Molecular characterization
  • Orthobunyavirus

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

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