Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype

E. Susanne Johansson, Bo Niklasson, Robert B. Tesh, Darren R. Shafren, Amelia P A Travassos da Rosa, A. Michael Lindberg

Research output: Contribution to journalArticle

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Abstract

Ljungan virus (LV) is a suspected human pathogen recently isolated from bank voles in Sweden. This study describes the genetic characterization of a virus, M1146, which was isolated in 1962 from another vole species (Microtus montanus), trapped in Oregon, USA. Based on antigenic properties, M1146 was postulated previously as a putative member of the family Picornaviridae. The near complete genomic sequence verifies that M1146 is a member of the Picornaviridae, most closely related to LVs isolated in Sweden. The strain M1146 possesses typical LV genomic organization, including a cluster of two 2A homologues. There are significant differences throughout the capsid protein region, while the non-structural region of M1146 is closely related to the Swedish LV genomes. Genetic and phylogenetic analyses show that M1146 represents a new genotype within the distinct LV cluster. Isolation of LV from both Swedish and American voles trapped over a period of 30 years suggests a continuous worldwide presence.

Original languageEnglish (US)
Pages (from-to)837-844
Number of pages8
JournalJournal of General Virology
Volume84
Issue number4
DOIs
StatePublished - Apr 1 2003

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Parechovirus
Arvicolinae
Genotype
Picornaviridae
Sweden
Capsid Proteins
Genome
Viruses

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Johansson, E. S., Niklasson, B., Tesh, R. B., Shafren, D. R., Travassos da Rosa, A. P. A., & Lindberg, A. M. (2003). Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype. Journal of General Virology, 84(4), 837-844. https://doi.org/10.1099/vir.0.18792-0

Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype. / Johansson, E. Susanne; Niklasson, Bo; Tesh, Robert B.; Shafren, Darren R.; Travassos da Rosa, Amelia P A; Lindberg, A. Michael.

In: Journal of General Virology, Vol. 84, No. 4, 01.04.2003, p. 837-844.

Research output: Contribution to journalArticle

Johansson, ES, Niklasson, B, Tesh, RB, Shafren, DR, Travassos da Rosa, APA & Lindberg, AM 2003, 'Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype', Journal of General Virology, vol. 84, no. 4, pp. 837-844. https://doi.org/10.1099/vir.0.18792-0
Johansson, E. Susanne ; Niklasson, Bo ; Tesh, Robert B. ; Shafren, Darren R. ; Travassos da Rosa, Amelia P A ; Lindberg, A. Michael. / Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype. In: Journal of General Virology. 2003 ; Vol. 84, No. 4. pp. 837-844.
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