Molecular Cytogenetic Characterization of a Recombinant Chromosome rec(22)dup(22q)inv(22)(p13q12.2)

Vijay S. Tonk, C. A. Jesurun, David L. Morgan, Lillian Lockhart, Gopalrao V N Velagaleti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pericentric inversions occur at a frequency of 0.12-0.7% in humans. However, pericentric inversions of chromosome 22 appear to be common, especially in patients originating from the Guadalajara region of Mexico. Here, we report a seventh case of a pericentric inversion of chromosome 22, the resulting recombinant chromosome, and describe the phenotypic features associated with such a recombinant chromosome. It is interesting that five of the seven patients with inv(22) come from Mexico, and four of the five patients from the Guadalajara region.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume124 A
Issue number1
StatePublished - Jan 1 2004

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Chromosomes, Human, Pair 22
Cytogenetics
Mexico
Chromosomes

Keywords

  • Distal 22q trisomy
  • Dysmorphism
  • Pericentric inversion
  • Recombinant

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Molecular Cytogenetic Characterization of a Recombinant Chromosome rec(22)dup(22q)inv(22)(p13q12.2). / Tonk, Vijay S.; Jesurun, C. A.; Morgan, David L.; Lockhart, Lillian; Velagaleti, Gopalrao V N.

In: American Journal of Medical Genetics, Vol. 124 A, No. 1, 01.01.2004, p. 92-95.

Research output: Contribution to journalArticle

Tonk, Vijay S. ; Jesurun, C. A. ; Morgan, David L. ; Lockhart, Lillian ; Velagaleti, Gopalrao V N. / Molecular Cytogenetic Characterization of a Recombinant Chromosome rec(22)dup(22q)inv(22)(p13q12.2). In: American Journal of Medical Genetics. 2004 ; Vol. 124 A, No. 1. pp. 92-95.
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