@article{8eca1b8e69fd41d8b217795e63e5b766,
title = "Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus",
abstract = "The 2015-2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a major public health concern. ZIKV is associated with fetal microcephaly and neurological complications, and countermeasures are needed to treat and prevent ZIKV infection. We report the isolation of 13 specific human monoclonal antibodies from a single patient infected with ZIKV. Two of the isolated antibodies (Z23 and Z3L1) demonstrated potent ZIKV-specific neutralization in vitro without binding or neutralizing activity against strains 1 to 4 of dengue virus, the closest relative to ZIKV. These two antibodies provided postexposure protection to mice in vivo. Structural studies revealed that Z23 and Z3L1 bound to tertiary epitopes in envelope protein domain I, II, or III, indicating potential targets for ZIKV-specific therapy. Our results suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines.",
author = "Qihui Wang and Huabing Yang and Xiaoqing Liu and Lianpan Dai and Tong Ma and Jianxun Qi and Gary Wong and Ruchao Peng and Sheng Liu and Junfu Li and Shihua Li and Jian Song and Jianying Liu and Jianhua He and Hui Yuan and Ying Xiong and Yong Liao and Jianhua Li and Jianping Yang and Zhou Tong and Griffin, {Bryan D.} and Yuhai Bi and Mifang Liang and Xiaoning Xu and Chuan Qin and Gong Cheng and Xinzheng Zhang and Peiyi Wang and Xiangguo Qiu and Gary Kobinger and Yi Shi and Jinghua Yan and Gao, {George F.}",
note = "Funding Information: This work was supported by the State Key Research Development Program of China (grant no. 2016YFC1200300) and the Zika Special Project of the Ministry of Science and Technology Reform and Development Project. B.D.G., X.Q., and G.K. were partially supported by the Public Health Agency of Canada. G.W. is the recipient of a Banting Postdoctoral Fellowship from the Canadian Institutes of Health Research and the President's International Fellowship Initiative from the CAS. G.C. is supported by the National Natural Science Foundation of China (NSFC; grant nos. 81422028 and 81571975). Y.S. is supported by the Excellent Young Scientist Program of CAS and the Youth Innovation Promotion Association of CAS (grant no. 2015078). Q.W. is supported by Young Elite Scientist Sponsorship Program by China Association for Science and Technology. G.F.G. is a leading principal investigator of the NSFC Innovative Research Group (grant no. 81321063). Publisher Copyright: {\textcopyright} 2016 The Authors.",
year = "2016",
month = dec,
day = "14",
doi = "10.1126/scitranslmed.aai8336",
language = "English (US)",
volume = "8",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "369",
}