Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India

Kamran Zaman; Prem Shankar; Pragya D. Yadav; Dimpal A. Nyayanit; Sthita Pragnya Behera; Pooja Bhardwaj; Anita Shete; Triparna Majumdar; Rajaram Yadav; Savita Patil; Hirawati Deval; Gaurav Raj Dwivedi; Ashok K. Pandey; Rajeev Singh; Brij R. Misra; Niraj Kumar; Kaushik Kumar; Priyanka Yadav; Girijesh Kumar Yadav; Manoj Kumar; Kamlesh Kumar Sah; Ravi Shankar Singh; Sanjeev Kumar; Asif Kavathekar; Vijay Kumar; Rajni Kant

doi:10.1017/S0950268821001989

Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India

Kamran Zaman, Prem Shankar, Pragya D. Yadav, Dimpal A. Nyayanit, Sthita Pragnya Behera, Pooja Bhardwaj, Anita Shete, Triparna Majumdar, Rajaram Yadav, Savita Patil, Hirawati Deval, Gaurav Raj Dwivedi, Ashok K. Pandey, Rajeev Singh, Brij R. Misra, Niraj Kumar, Kaushik Kumar, Priyanka Yadav, Girijesh Kumar Yadav, Manoj KumarKamlesh Kumar Sah, Ravi Shankar Singh, Sanjeev Kumar, Asif Kavathekar, Vijay Kumar, Rajni Kant

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2 Scopus citations

Abstract

We report a familial cluster of 24 individuals infected with severe acute respiratory syndromecoronavirus- 2 (SARS-CoV-2). The index case had a travel history and spent 24 days in the house before being tested and was asymptomatic. Physical overcrowding in the house provided a favourable environment for intra-cluster infection transmission. Restriction of movement of family members due to countrywide lockdown limited the spread in community. Among the infected, only four individuals developed symptoms. The complete genome sequences of SARS-CoV-2 was retrieved using next-generation sequencing from eight clinical samples which demonstrated a 99.99% similarity with reference to Wuhan strain and the phylogenetic analysis demonstrated a distinct cluster, lying in the B.6.6 pangolin lineage.

Original language	English (US)
Article number	e200
Journal	Epidemiology and infection
Volume	149
DOIs	https://doi.org/10.1017/S0950268821001989
State	Published - 2021
Externally published	Yes

Keywords

Familial cluster
India
SARS-CoV-2
Uttar Pradesh
next-generation sequencing

ASJC Scopus subject areas

Infectious Diseases
Epidemiology

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10.1017/S0950268821001989

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Zaman, K., Shankar, P., Yadav, P. D., Nyayanit, D. A., Behera, S. P., Bhardwaj, P., Shete, A., Majumdar, T., Yadav, R., Patil, S., Deval, H., Dwivedi, G. R., Pandey, A. K., Singh, R., Misra, B. R., Kumar, N., Kumar, K., Yadav, P., Yadav, G. K., ... Kant, R. (2021). Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India. Epidemiology and infection, 149, Article e200. https://doi.org/10.1017/S0950268821001989

Zaman, K, Shankar, P, Yadav, PD, Nyayanit, DA, Behera, SP, Bhardwaj, P, Shete, A, Majumdar, T, Yadav, R, Patil, S, Deval, H, Dwivedi, GR, Pandey, AK, Singh, R, Misra, BR, Kumar, N, Kumar, K, Yadav, P, Yadav, GK, Kumar, M, Sah, KK, Singh, RS, Kumar, S, Kavathekar, A, Kumar, V & Kant, R 2021, 'Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India', Epidemiology and infection, vol. 149, e200. https://doi.org/10.1017/S0950268821001989

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title = "Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India",

abstract = "We report a familial cluster of 24 individuals infected with severe acute respiratory syndromecoronavirus- 2 (SARS-CoV-2). The index case had a travel history and spent 24 days in the house before being tested and was asymptomatic. Physical overcrowding in the house provided a favourable environment for intra-cluster infection transmission. Restriction of movement of family members due to countrywide lockdown limited the spread in community. Among the infected, only four individuals developed symptoms. The complete genome sequences of SARS-CoV-2 was retrieved using next-generation sequencing from eight clinical samples which demonstrated a 99.99% similarity with reference to Wuhan strain and the phylogenetic analysis demonstrated a distinct cluster, lying in the B.6.6 pangolin lineage.",

keywords = "Familial cluster, India, SARS-CoV-2, Uttar Pradesh, next-generation sequencing",

author = "Kamran Zaman and Prem Shankar and Yadav, {Pragya D.} and Nyayanit, {Dimpal A.} and Behera, {Sthita Pragnya} and Pooja Bhardwaj and Anita Shete and Triparna Majumdar and Rajaram Yadav and Savita Patil and Hirawati Deval and Dwivedi, {Gaurav Raj} and Pandey, {Ashok K.} and Rajeev Singh and Misra, {Brij R.} and Niraj Kumar and Kaushik Kumar and Priyanka Yadav and Yadav, {Girijesh Kumar} and Manoj Kumar and Sah, {Kamlesh Kumar} and Singh, {Ravi Shankar} and Sanjeev Kumar and Asif Kavathekar and Vijay Kumar and Rajni Kant",

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year = "2021",

doi = "10.1017/S0950268821001989",

language = "English (US)",

volume = "149",

journal = "Epidemiology and infection",

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T1 - Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India

AU - Zaman, Kamran

AU - Shankar, Prem

AU - Yadav, Pragya D.

AU - Nyayanit, Dimpal A.

AU - Behera, Sthita Pragnya

AU - Bhardwaj, Pooja

AU - Shete, Anita

AU - Majumdar, Triparna

AU - Yadav, Rajaram

AU - Patil, Savita

AU - Deval, Hirawati

AU - Dwivedi, Gaurav Raj

AU - Pandey, Ashok K.

AU - Singh, Rajeev

AU - Misra, Brij R.

AU - Kumar, Niraj

AU - Kumar, Kaushik

AU - Yadav, Priyanka

AU - Yadav, Girijesh Kumar

AU - Kumar, Manoj

AU - Sah, Kamlesh Kumar

AU - Singh, Ravi Shankar

AU - Kumar, Sanjeev

AU - Kavathekar, Asif

AU - Kumar, Vijay

AU - Kant, Rajni

PY - 2021

Y1 - 2021

N2 - We report a familial cluster of 24 individuals infected with severe acute respiratory syndromecoronavirus- 2 (SARS-CoV-2). The index case had a travel history and spent 24 days in the house before being tested and was asymptomatic. Physical overcrowding in the house provided a favourable environment for intra-cluster infection transmission. Restriction of movement of family members due to countrywide lockdown limited the spread in community. Among the infected, only four individuals developed symptoms. The complete genome sequences of SARS-CoV-2 was retrieved using next-generation sequencing from eight clinical samples which demonstrated a 99.99% similarity with reference to Wuhan strain and the phylogenetic analysis demonstrated a distinct cluster, lying in the B.6.6 pangolin lineage.

AB - We report a familial cluster of 24 individuals infected with severe acute respiratory syndromecoronavirus- 2 (SARS-CoV-2). The index case had a travel history and spent 24 days in the house before being tested and was asymptomatic. Physical overcrowding in the house provided a favourable environment for intra-cluster infection transmission. Restriction of movement of family members due to countrywide lockdown limited the spread in community. Among the infected, only four individuals developed symptoms. The complete genome sequences of SARS-CoV-2 was retrieved using next-generation sequencing from eight clinical samples which demonstrated a 99.99% similarity with reference to Wuhan strain and the phylogenetic analysis demonstrated a distinct cluster, lying in the B.6.6 pangolin lineage.

KW - Familial cluster

KW - India

KW - SARS-CoV-2

KW - Uttar Pradesh

KW - next-generation sequencing

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Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India

Abstract

Keywords

ASJC Scopus subject areas

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